S1PR1

Gene Symbol S1PR1
Entrez Gene 1901
Alt Symbol CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
Species Human
Gene Type protein-coding
Description sphingosine-1-phosphate receptor 1
Other Description S1P receptor 1|S1P receptor Edg-1|endothelial differentiation G-protein coupled receptor 1|endothelial differentiation, sphingolipid G-protein-coupled receptor, 1|sphingosine 1-phosphate receptor 1|sphingosine 1-phosphate receptor EDG1|sphingosine 1-phosphate receptor Edg-1
Swissprots Q9NYN8 Q9BYY4 D3DT66 P21453
Accessions AAK01993 EAW72927 EAW72928 P21453 AF022137 AAC51905 AF233365 AAF43420 AK297005 BAG59541 AK312493 BAG35395 BC018650 AAH18650 BI598518 BU677564 CF994197 CR541786 CAG46585 CR542269 CAG47065 CR977007 DB132417 DB572979 M31210 AAA52336 XM_006710399 XP_006710462 NM_001400 NP_001391
Function G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation
Subcellular Location Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl- 2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Tissue Specificity Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Top Pathways Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction

EDG-1 (F-6) - sc-271423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EDG-1 (F-6): sc-271423. Western blot analysis of EDG-1 expression in human recombinant fusion protein.

EDG-1 (A-6) - sc-48356 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EDG-1 (A-6): sc-48356. Immunoperoxidase staining of formalin fixed, paraffin-embedded human reanl cancer tissue showing membrane and cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

EDG-1 (H-60) - sc-25489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EDG-1 (H-60): sc-25489. Western blot analysis of human recombinant EDG-1 fusion protein.

EDG-1 (P-20) - sc-16070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EDG-1 (P-20): sc-16070. Western blot analysis of EDG-1 expression in human brain tissue extract.

EDG-1 (V-18) - sc-31625 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-EDG1 (phospho T236) antibody - ab111571 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111571, at 1/100 dilution, staining EDG1 in COS-7 cells by Immunofluorescence, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-EDG1 antibody - ab77076 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-EDG1 antibody (ab77076) at 1 µg/mlLane 2 : Anti-EDG1 antibody (ab77076) at 2 µg/mlLane 1 : mouse thymus tissue lysateLane 2 : mouse thymus tissue lysateLysates/proteins at 15 µg per lane.

Anti-EDG1 antibody - ab54948 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EDG1 antibody - ab23695 from Abcam

Prices $390.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EDG1 antibody (ab23695) at 2 µg/mlLane 1 : 30ug of human liver microsomes.Lane 2 : 30ug mouse brain homogenate.Lane 3 : 30ug pig liver 10000 x g supernatantLane 4 : 30ug rat brain homogenate.

Anti-EDG1 antibody [EPR4538(2)] - ab125074 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4538(2)
All lanes : Anti-EDG1 antibody [EPR4538(2)] (ab125074) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : HUVEC cell lysateLane 4 : A375 cell lysateLysates/proteins at 10 µg per lane.

Anti-EDG1 antibody [MM0044-7M15] - ab72806 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0044-7M15

Anti-EDG1 antibody - Aminoterminal end - ab60038 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab60038 at 1/50 dilution staining EDG1 in Human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

Anti-EDG1 antibody - C-terminal - ab137467 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-EDG1 antibody - C-terminal (ab137467) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-S1PR1 / EDG1 / S1P1 Antibody (C-Terminus) - LS-C22990 from LifeSpan Bioscience

Prices $755.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-S1PR1 / EDG1 / S1P1 Antibody (clone 218713, APC) - LS-C65191 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 218713

Anti-S1PR1 / EDG1 / S1P1 Antibody (clone 218713, PE) - LS-C65192 from LifeSpan Bioscience

Prices $545.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 218713

Anti-S1PR1 / EDG1 / S1P1 Antibody (C-Terminus) IHC-plus™ - LS-A1012 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-S1PR1 / EDG1 / S1P1 Antibody (aa241-253) - LS-C11168 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Western blot of EDG1 / S1P1 antibody LS-C11168.

Anti-S1PR1 / EDG1 / S1P1 Antibody - LS-C121198 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-S1PR1 / EDG1 / S1P1 Antibody (C-Terminus) - LS-C83928 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of S1P1 in mouse thymus lysate with S1P1 antibody at (A) 1 and (B) 2 ug/ml.

Anti-S1PR1 / EDG1 / S1P1 Antibody (aa10-39) - LS-C100385 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of hEDG1-I25 in mouse lung tissue lysates (35 ug/lane). EDG1 (arrow) was detected using the purified antibody.

Anti-S1PR1 / EDG1 / S1P1 Antibody (aa340-400) - LS-C148470 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-S1PR1 / EDG1 / S1P1 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1013 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human, Vascular Endothelium: Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-S1PR1 / EDG1 / S1P1 Antibody (aa206-255) - LS-C118016 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using S1P Receptor EDG1 (Ab-236) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-S1PR1 / EDG1 / S1P1 Antibody (aa350-400) - LS-C148693 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of S1PR1 in human kidney lysate in the 1) absence, 2) presence of immunizing peptide and 3) rat kidney lysate using S1PR1 antibody at 5 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
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