| Gene Symbol |
HMSD
|
| Entrez Gene |
284293
|
| Alt Symbol |
ACC-6, ACC6, C18orf53, HSMD-v
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histocompatibility (minor) serpin domain containing
|
| Other Description |
minor histocompatibility protein HMSD|serpin-like protein HMSD
|
| Swissprots |
A8MTL9 P0C7T4
|
| Accessions |
A8MTL9 AW205887 BM696260 XM_011525930 XP_011524232 NM_001123366 NP_001116838
|
| Function |
This allelic splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6
|
| Tissue Specificity |
Highly expressed in dendritic cells and primary leukemia cells, especially those of myeloid lineage. ACC-6 expression is limited to cells of the hematopoietic lineage. {ECO:0000269|PubMed:17409267}.
|