HMSD

Gene Symbol HMSD
Entrez Gene 284293
Alt Symbol ACC-6, ACC6, C18orf53, HSMD-v
Species Human
Gene Type protein-coding
Description histocompatibility (minor) serpin domain containing
Other Description minor histocompatibility protein HMSD|serpin-like protein HMSD
Swissprots A8MTL9 P0C7T4
Accessions A8MTL9 AW205887 BM696260 XM_011525930 XP_011524232 NM_001123366 NP_001116838
Function This allelic splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6
Tissue Specificity Highly expressed in dendritic cells and primary leukemia cells, especially those of myeloid lineage. ACC-6 expression is limited to cells of the hematopoietic lineage. {ECO:0000269|PubMed:17409267}.

Recombinant Human Minor histocompatibility protein HMSD variant form(HMSD) - CSB-YP315208HU CSB-EP315208HU CSB-BP315208HU CSB-MP315208HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Recombinant Human Serpin-like protein HMSD(HMSD) - CSB-YP010585HU CSB-EP010585HU CSB-BP010585HU CSB-MP010585HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

HMSD Peptide, Human - M34GP07138H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Minor histocompatibility protein HMSD variant form (HMSD), Recombinant Protein - MBS1058360 from MyBioSource

Category Protein
Prices $780.00, $780.00, $1,000.00, $1,000.00, $1,080.00, $1,080.00, $1,540.00, $1,540.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Serpin-like protein HMSD (HMSD), Recombinant Protein - MBS1154459 from MyBioSource

Category Protein
Prices $855.00, $855.00, $1,080.00, $1,080.00, $1,235.00, $1,235.00, $1,695.00, $1,695.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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