HMSD

Gene Symbol HMSD
Entrez Gene 284293
Alt Symbol ACC-6, ACC6, C18orf53, HSMD-v
Species Human
Gene Type protein-coding
Description histocompatibility (minor) serpin domain containing
Other Description minor histocompatibility protein HMSD|serpin-like protein HMSD
Swissprots A8MTL9 P0C7T4
Accessions A8MTL9 AW205887 BM696260 XM_011525930 XP_011524232 NM_001123366 NP_001116838
Function This allelic splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6
Tissue Specificity Highly expressed in dendritic cells and primary leukemia cells, especially those of myeloid lineage. ACC-6 expression is limited to cells of the hematopoietic lineage. {ECO:0000269|PubMed:17409267}.

HMSD CRISPR/Cas9 KO Plasmid (h) - sc-418642 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMSD HDR Plasmid (h) - sc-418642-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMSD Double Nickase Plasmid (h) - sc-418642-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMSD Double Nickase Plasmid (h2) - sc-418642-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMSD CRISPR Activation Plasmid (h) - sc-418642-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMSD CRISPR Activation Plasmid (h2) - sc-418642-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMSD Lentiviral Activation Particles (h) - sc-418642-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMSD Lentiviral Activation Particles (h2) - sc-418642-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10183 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10183 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HMSD siRNA (Human) - CRJ6990 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HMSD - MBS8203233 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HMSD (NM_001123366.1) - SHH313553 from Creative biogene

Category siRNA
Species Reactivities Human

HMSD shRNA Plasmid (Human) - CHJ6990 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HMSD miRNA 3'UTR clone - MiUTR3H-12293 from Creative biogene

Species Reactivities Human
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