Gene Symbol | CXCL1 |
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Entrez Gene | 2919 |
Alt Symbol | FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
Other Description | C-X-C motif chemokine 1|GRO-alpha(1-73)|GRO1 oncogene (melanoma growth stimulating activity, alpha)|GRO1 oncogene (melanoma growth-stimulating activity)|MGSA alpha|fibroblast secretory protein|growth-regulated alpha protein|melanoma growth stimulatory activity alpha|neutrophil-activating protein 3 |
Swissprots | P09341 Q9UCR7 |
Accessions | AAA03452 AAP13103 CAA38361 CBX54348 CCD62019 EAX05693 P09341 BC011976 AAH11976 BG121608 BM554448 BM996663 BQ000742 BT006880 AAP35526 CB112830 DQ893591 ABM84517 DQ894941 ABM85867 J03561 AAA35933 X12510 CAA31027 NM_001511 NP_001502 NR_046035 |
Function | Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. {ECO:0000269|PubMed:10095777}. |
Subcellular Location | Secreted. |
Top Pathways | TNF signaling pathway, Cytokine-cytokine receptor interaction, Legionellosis, Salmonella infection, Rheumatoid arthritis |
GROα CRISPR/Cas9 KO Plasmid (h) - sc-403256 from Santa Cruz Biotechnology
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GROα HDR Plasmid (h) - sc-403256-HDR from Santa Cruz Biotechnology
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GROα Double Nickase Plasmid (h) - sc-403256-NIC from Santa Cruz Biotechnology
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GROα Double Nickase Plasmid (h2) - sc-403256-NIC-2 from Santa Cruz Biotechnology
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GROα CRISPR Activation Plasmid (h) - sc-403256-ACT from Santa Cruz Biotechnology
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GROα CRISPR Activation Plasmid (h2) - sc-403256-ACT-2 from Santa Cruz Biotechnology
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GROα Lentiviral Activation Particles (h) - sc-403256-LAC from Santa Cruz Biotechnology
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GROα Lentiviral Activation Particles (h2) - sc-403256-LAC-2 from Santa Cruz Biotechnology
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GROα siRNA (h) - sc-43816 from Santa Cruz Biotechnology
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GROα shRNA Plasmid (h) - sc-43816-SH from Santa Cruz Biotechnology
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GROα shRNA (h) Lentiviral Particles - sc-43816-V from Santa Cruz Biotechnology
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GRO alpha RNAi - H00002919-R01 from Novus Biologicals
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MISSION® esiRNA - EHU112651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6796 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6796 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05775 from Sigma-Aldrich
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CXCL1 siRNA (Human) - CRH1972 from Cohesion Biosciences
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CXCL1 - MBS8205373 from MyBioSource
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shRNA set against Human CXCL1 (NM_001511.3) - SHH272105 from Creative biogene
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CXCL1 shRNA Plasmid (Human) - CHH1972 from Cohesion Biosciences
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CXCL1 miRNA 3'UTR clone - MiUTR3H-01389 from Creative biogene
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