| Gene Symbol |
IPO5
|
| Entrez Gene |
3843
|
| Alt Symbol |
IMB3, KPNB3, Pse1, RANBP5, imp5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
importin 5
|
| Other Description |
RAN binding protein 5|Ran_GTP binding protein 5|importin beta-3 subunit|importin subunit beta-3|importin-5|karyopherin (importin) beta 3|karyopherin beta-3|ran-binding protein 5
|
| Swissprots |
Q5T578 O15257 Q86XC7 B4DZA0 O00410
|
| Accessions |
EAX08977 EAX08978 EAX08979 EAX08980 EAX08981 O00410 AB074173 AF339834 AK125031 BAG54128 AK225286 AK302812 BAG64012 AK303494 BAG64528 AL705630 BC000947 AAH00947 BC001497 AAH01497 BC019309 AAH19309 BC045640 AAH45640 BM666295 BU618294 BX648222 DQ893033 ABM83959 EU176755 ABW03556 U72761 AAC51317 Y08890 CAA70103 XM_005254052 XP_005254109 XM_005254053 XP_005254110 XM_011521087 XP_011519389 XM_011521088 XP_011519390 XM_011521089 XP_011519391 XM_011521090 XP_011519392 NM_002271 NP_002262
|
| Function |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.
|