IPO5

Gene Symbol	IPO5
Entrez Gene	3843
Alt Symbol	IMB3, KPNB3, Pse1, RANBP5, imp5
Species	Human
Gene Type	protein-coding
Description	importin 5
Other Description	RAN binding protein 5|Ran_GTP binding protein 5|importin beta-3 subunit|importin subunit beta-3|importin-5|karyopherin (importin) beta 3|karyopherin beta-3|ran-binding protein 5
Swissprots	Q5T578 O15257 Q86XC7 B4DZA0 O00410
Accessions	EAX08977 EAX08978 EAX08979 EAX08980 EAX08981 O00410 AB074173 AF339834 AK125031 BAG54128 AK225286 AK302812 BAG64012 AK303494 BAG64528 AL705630 BC000947 AAH00947 BC001497 AAH01497 BC019309 AAH19309 BC045640 AAH45640 BM666295 BU618294 BX648222 DQ893033 ABM83959 EU176755 ABW03556 U72761 AAC51317 Y08890 CAA70103 XM_005254052 XP_005254109 XM_005254053 XP_005254110 XM_011521087 XP_011519389 XM_011521088 XP_011519390 XM_011521089 XP_011519391 XM_011521090 XP_011519392 NM_002271 NP_002262
Function	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Karyopherin beta 3 protein fragment - ab114896 from Abcam Category Protein Source Wheat germ Species Human

IMP5 Antibody Blocking Peptide - LS-E19253 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IPO5 / RANBP5 Antibody Blocking Peptide - LS-E19367 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Karyopherin (importin) beta 3 Protein - H00003843-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RANBP5-Antibody-C-term-Blocking-peptide - BP9108b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RANBP5-Antibody-N-term-Blocking-Peptide - BP9108a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KPNB3/RANBP5 blocking peptide - GTX89746-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

IMP5 Blocking Peptide - 33R-6817 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RANBP5 Blocking Peptide - 33R-3453 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RanBP5 / Importin-5 - H00003843-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RanBP5 / Importin-5 - H00003843-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human IPO5 - IPO5-27548TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Importin-5(IPO5) ,partial - CSB-YP011778HU CSB-EP011778HU CSB-BP011778HU CSB-MP011778HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Karyopherin (importin) beta 3 Recombinant Protein Antigen - NBP2-38480PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Karyopherin (importin) beta 3 Recombinant Protein Antigen - NBP2-38795PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IPO5 Peptide, Human - M34GP07704H from Creative Peptides Category Peptide Source Synthetic. Species Human

Importin-5 (IPO5), partial, Recombinant Protein - MBS1021045 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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