IPO5

Gene Symbol IPO5
Entrez Gene 3843
Alt Symbol IMB3, KPNB3, Pse1, RANBP5, imp5
Species Human
Gene Type protein-coding
Description importin 5
Other Description RAN binding protein 5|Ran_GTP binding protein 5|importin beta-3 subunit|importin subunit beta-3|importin-5|karyopherin (importin) beta 3|karyopherin beta-3|ran-binding protein 5
Swissprots Q5T578 O15257 Q86XC7 B4DZA0 O00410
Accessions EAX08977 EAX08978 EAX08979 EAX08980 EAX08981 O00410 AB074173 AF339834 AK125031 BAG54128 AK225286 AK302812 BAG64012 AK303494 BAG64528 AL705630 BC000947 AAH00947 BC001497 AAH01497 BC019309 AAH19309 BC045640 AAH45640 BM666295 BU618294 BX648222 DQ893033 ABM83959 EU176755 ABW03556 U72761 AAC51317 Y08890 CAA70103 XM_005254052 XP_005254109 XM_005254053 XP_005254110 XM_011521087 XP_011519389 XM_011521088 XP_011519390 XM_011521089 XP_011519391 XM_011521090 XP_011519392 NM_002271 NP_002262
Function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-
Subcellular Location Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

karyopherin β3 (A-18) - sc-84578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
karyopherin β3 (A-18): sc-84578. Western blot analysis of karyopherin β3 expression in non-transfected 293T: sc-117752 (A), human karyopherin β3 transfected 293T: sc-173029 (B) and HeLa (C) whole cell lysates.

karyopherin β3 (B-7) - sc-55527 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
karyopherin β3 (B-7): sc-55527. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

karyopherin β3 (E-4) - sc-17801 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
karyopherin β3 (E-4): sc-17801. Western blot analysis of karyopherin β3 expression in HeLa (A), Jurkat (B), HEL 92.1.7 (C) and NIH/3T3 (D) whole cell lysates.

karyopherin β3 (H-300) - sc-11369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
karyopherin β3 (H-300): sc-11369. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic and nuclear staining of cells in seminiferous ducts and Leydig cells.

karyopherin β3 (H-4) - sc-17802 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
karyopherin β3 siRNA (h): sc-35740. Western blot analysis of karyopherin β3 expression in non-transfected control (A) and karyopherin β3 siRNA transfected (B) HeLa cells. Blot probed with karyopherin β3 (H-4): sc-17802. α-actinin (H-2): sc-17829 used as specificity and loading control.

Anti-Karyopherin beta 3 antibody - ab187175 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling Karyopherin beta 3 with ab187175 at 1/200. Magnification: 400x.

Anti-Karyopherin beta 3 antibody [1C4] - ab124637 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C4
ab124637, at 5µg/mL, staining Human testis by immunohistochemistry of paraffin embedded tissues (IHC-P).

Anti-Karyopherin beta 3 antibody - N-terminal - ab137522 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Karyopherin beta 3 antibody - N-terminal (ab137522) at 1/2000 dilutionLane 1 : NT2D1 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Karyopherin beta 3 antibody - ab88695 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Karyopherin beta 3 antibody (ab88695) at 1 µg/ml + rat brain tissue lysate at 50 µg

Anti-Karyopherin beta 3 antibody - ab55390 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Karyopherin (importin) beta 3 antibody (ab55390) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human pancreas.

Anti-PSE1 antibody [N9C1] - ab822 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone N9C1

Anti-IPO5 / RANBP5 Antibody (clone 1C4) IHC-plus™ - LS-B6107 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C4
Anti-IPO5 / Importin 5 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6107 concentration 5 ug/ml.

Anti-IPO5 / RANBP5 Antibody - LS-C331805 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat lung using IPO5 antibody at dilution of 1:200 (400x lens).

Anti-IPO5 / RANBP5 Antibody (aa1-101, Azide-free) - LS-C327698 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-IPO5 / RANBP5 Antibody - LS-C341396 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IPO5 / RANBP5 Antibody - LS-C308688 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IPO5 / RANBP5 Antibody (aa143-192) - LS-C117256 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IPO5 / Importin 5 antibody LS-C117256 Western blot of Jurkat lysate.

Karyopherin (importin) beta 3 Antibody (1C4) - H00003843-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C4

Karyopherin (importin) beta 3 Antibody - NBP2-17016 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Karyopherin (importin) beta 3 Antibody - H00003843-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Karyopherin (importin) beta 3 Antibody [H00003843-B01P] - Analysis of RANBP5 expression in rat brain.

Karyopherin (importin) beta 3 Antibody - NBP2-38795 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Karyopherin (importin) beta 3 Antibody - NBP1-79535 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

Karyopherin (importin) beta 3 Antibody - NBP2-38480 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Karyopherin (importin) beta 3 Antibody [NBP2-38480] - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts.

Anti-RANBP5 antibody produced in mouse - SAB1406068 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-RANBP5: <B>Cat. No. SAB1406068</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Anti-Importin 5 (N-terminal) antibody produced in rabbit - SAB4200178 from Sigma-Aldrich

Prices $322.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B> <BR/>HEK-293T cells expressing human Importin 5 were fixed and stained with 5 μg/mL Rabbit Anti-Importin 5 (N-terminal) (<B>Cat. No. SAB4200178</B>) followed by Goat Anti-Rabbit, Cy3 conjugate and counterstained with DAPI (blue) to stain nuclei (×40 magnification).
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