SVIL

Gene Symbol	SVIL
Entrez Gene	6840
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	supervillin
Other Description	archvillin|membrane-associated F-actin binding protein p205|p205/p250
Swissprots	Q5VZK5 O60612 D3DRW9 Q9H1R7 M1J557 O60611 O95425 Q5VZK6
Accessions	CCO13826 EAW86018 EAW86019 EAW86020 O95425 AF051850 AAC64695 AF051851 AAC64696 AF109135 AAD14682 AI028650 AK001792 AK302077 BAG63466 AK304720 BAG65483 AK304799 BAG65549 AK307640 AK310272 AL117410 CAH56399 BC057241 BC070247 BC092440 AAH92440 BC172362 AAI72362 BX457194 BX648589 CAH56147 JX467682 AGE81989 XM_005252570 XP_005252627 XM_005252571 XP_005252628 XM_005252573 XP_005252630 XM_011519630 XP_011517932 XM_011519631 XP_011517933 XM_011519632 XP_011517934 XM_011519633 XP_011517935 XM_011519634 XP_011517936 XM_011519635 XP_011517937 XM_011519636 XP_011517938 XM_011519637 XP_011517939 XM_011519638 XP_011517940 XM_011519639 XP_011517941 XM_011519640 XP_011517942 NM_003174 NP_003165 NM_021738 NP_068506
Function	Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O46385}.
Subcellular Location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody {ECO:0000250|UniProtKB:O46385}. Cleavage furrow {ECO:0000250|UniProtKB:O46385}. Note=Tightly associated with both actin filaments and plasma membranes.
Tissue Specificity	Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. {ECO:0000269|PubMed:9867483}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Supervillin (A-12) - sc-393135 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Supervillin (N-15) - sc-47434 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Supervillin (H-300) - sc-366386 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Supervillin (B8C1) - sc-53556 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-Supervillin antibody - ab50856 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Supervillin antibody - ab57462 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SVIL / Supervillin Antibody (aa1385-1525) - LS-C296542 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SVIL / Supervillin Antibody (aa1617-1788) - LS-C296545 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SVIL / Supervillin Antibody (aa1385-1525, Biotin) - LS-C300430 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SVIL / Supervillin Antibody (aa1617-1788, Biotin) - LS-C301130 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SVIL / Supervillin Antibody (aa1617-1788, FITC) - LS-C302503 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SVIL / Supervillin Antibody (aa1385-1525, FITC) - LS-C303312 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SVIL / Supervillin Antibody (aa1385-1525) - LS-C314287 from LifeSpan Bioscience Prices $415.00 Sizes 200 µg Host Mouse Clonality Monoclonal

Anti-SVIL / Supervillin Antibody (clone 6E10) - LS-C198291 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6E10

Supervillin Antibody - AF7338 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Supervillin Antibody - NBP1-90363 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Supervillin Antibody (6E10.) - H00006840-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6E10.

Supervillin Antibody - NBP1-87559 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Supervillin Antibody - H00006840-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Supervillin Polyclonal Antibody - bs-7123R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Supervillin antibody produced in rabbit - S8695 from Sigma-Aldrich Prices $402.50 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SVIL antibody produced in rabbit - HPA020138 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Archvillin antibody produced in rabbit - A1355 from Sigma-Aldrich Prices $428.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-SVIL antibody produced in mouse - WH0006840M3 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6E10

SVIL-Antibody-monoclonal-M03 - AT4117a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6E11

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