SVIL

Gene Symbol SVIL
Entrez Gene 6840
Alt Symbol -
Species Human
Gene Type protein-coding
Description supervillin
Other Description archvillin|membrane-associated F-actin binding protein p205|p205/p250
Swissprots Q5VZK5 O60612 D3DRW9 Q9H1R7 M1J557 O60611 O95425 Q5VZK6
Accessions CCO13826 EAW86018 EAW86019 EAW86020 O95425 AF051850 AAC64695 AF051851 AAC64696 AF109135 AAD14682 AI028650 AK001792 AK302077 BAG63466 AK304720 BAG65483 AK304799 BAG65549 AK307640 AK310272 AL117410 CAH56399 BC057241 BC070247 BC092440 AAH92440 BC172362 AAI72362 BX457194 BX648589 CAH56147 JX467682 AGE81989 XM_005252570 XP_005252627 XM_005252571 XP_005252628 XM_005252573 XP_005252630 XM_011519630 XP_011517932 XM_011519631 XP_011517933 XM_011519632 XP_011517934 XM_011519633 XP_011517935 XM_011519634 XP_011517936 XM_011519635 XP_011517937 XM_011519636 XP_011517938 XM_011519637 XP_011517939 XM_011519638 XP_011517940 XM_011519639 XP_011517941 XM_011519640 XP_011517942 NM_003174 NP_003165 NM_021738 NP_068506
Function Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O46385}.
Subcellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody {ECO:0000250|UniProtKB:O46385}. Cleavage furrow {ECO:0000250|UniProtKB:O46385}. Note=Tightly associated with both actin filaments and plasma membranes.
Tissue Specificity Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. {ECO:0000269|PubMed:9867483}.

Supervillin CRISPR/Cas9 KO Plasmid (h) - sc-403872 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin HDR Plasmid (h) - sc-403872-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin Double Nickase Plasmid (h) - sc-403872-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin Double Nickase Plasmid (h2) - sc-403872-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin CRISPR Activation Plasmid (h) - sc-403872-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin CRISPR Activation Plasmid (h2) - sc-403872-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin Lentiviral Activation Particles (h) - sc-403872-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin Lentiviral Activation Particles (h2) - sc-403872-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Supervillin siRNA (h) - sc-61624 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Supervillin shRNA Plasmid (h) - sc-61624-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Supervillin shRNA (h) Lentiviral Particles - sc-61624-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Supervillin RNAi - H00006840-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN20866 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20866 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06688 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06688

SVIL siRNA (Human) - CRH4678 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Supervillin RNAi - H00006840-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SVIL - MBS8224362 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SVIL (NM_003174.3) - SHH421320 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SVIL(NM_021738.2) - SHL049212 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SVIL(NM_003174.3) - SHL049266 from Creative biogene

Category siRNA
Species Reactivities Human

SVIL shRNA Plasmid (Human) - CHH4678 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SVIL miRNA 3'UTR clone - MiUTR1H-10094 from Creative biogene

Species Reactivities Human

SVIL miRNA 3'UTR clone - MiUTR1H-10095 from Creative biogene

Species Reactivities Human
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