| Gene Symbol |
SVIL
|
| Entrez Gene |
6840
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
supervillin
|
| Other Description |
archvillin|membrane-associated F-actin binding protein p205|p205/p250
|
| Swissprots |
Q5VZK5 O60612 D3DRW9 Q9H1R7 M1J557 O60611 O95425 Q5VZK6
|
| Accessions |
CCO13826 EAW86018 EAW86019 EAW86020 O95425 AF051850 AAC64695 AF051851 AAC64696 AF109135 AAD14682 AI028650 AK001792 AK302077 BAG63466 AK304720 BAG65483 AK304799 BAG65549 AK307640 AK310272 AL117410 CAH56399 BC057241 BC070247 BC092440 AAH92440 BC172362 AAI72362 BX457194 BX648589 CAH56147 JX467682 AGE81989 XM_005252570 XP_005252627 XM_005252571 XP_005252628 XM_005252573 XP_005252630 XM_011519630 XP_011517932 XM_011519631 XP_011517933 XM_011519632 XP_011517934 XM_011519633 XP_011517935 XM_011519634 XP_011517936 XM_011519635 XP_011517937 XM_011519636 XP_011517938 XM_011519637 XP_011517939 XM_011519638 XP_011517940 XM_011519639 XP_011517941 XM_011519640 XP_011517942 NM_003174 NP_003165 NM_021738 NP_068506
|
| Function |
Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O46385}.
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody {ECO:0000250|UniProtKB:O46385}. Cleavage furrow {ECO:0000250|UniProtKB:O46385}. Note=Tightly associated with both actin filaments and plasma membranes.
|
| Tissue Specificity |
Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. {ECO:0000269|PubMed:9867483}.
|
![Western Blot: Supervillin Overexpression Lysate (Adult Normal) [NBP2-10875] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Supervillin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6920_Supervillin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10875-img0001.jpg)