Gene Symbol | Fgf8 |
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Entrez Gene | 14179 |
Alt Symbol | Aigf, Fgf-8 |
Species | Mouse |
Gene Type | protein-coding |
Description | fibroblast growth factor 8 |
Other Description | HBGF-8|androgen-induced growth factor|heparin-binding growth factor 8 |
Swissprots | P37237 |
Accessions | AAA61908 EDL41963 EDL41964 EDL41965 EDL41966 P37237 AK131980 BAE20919 BC048734 AAH48734 BU512456 D12482 BAA02050 D12483 BAA02051 HQ260698 AEN94297 U18673 AAA65387 Z48746 CAA88637 XM_006526668 XP_006526731 XM_011247142 XP_011245444 XM_011247143 XP_011245445 NM_001166361 NP_001159833 NM_001166362 NP_001159834 NM_001166363 NP_001159835 NM_010205 NP_034335 |
Function | Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus- induced murine mammary tumorigenesis (PubMed:7884899). {ECO:0000250|UniProtKB:P55075}. |
Subcellular Location | Secreted. |
Tissue Specificity | Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos. |
Top Pathways | Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton |
FGF-8 CRISPR/Cas9 KO Plasmid (m) - sc-420338 from Santa Cruz Biotechnology
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FGF-8 HDR Plasmid (m) - sc-420338-HDR from Santa Cruz Biotechnology
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FGF-8 Double Nickase Plasmid (m) - sc-420338-NIC from Santa Cruz Biotechnology
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FGF-8 Double Nickase Plasmid (m2) - sc-420338-NIC-2 from Santa Cruz Biotechnology
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FGF-8 CRISPR Activation Plasmid (m) - sc-420338-ACT from Santa Cruz Biotechnology
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FGF-8 CRISPR Activation Plasmid (m2) - sc-420338-ACT-2 from Santa Cruz Biotechnology
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FGF-8 Lentiviral Activation Particles (m) - sc-420338-LAC from Santa Cruz Biotechnology
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FGF-8 Lentiviral Activation Particles (m2) - sc-420338-LAC-2 from Santa Cruz Biotechnology
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FGF-8 siRNA (m) - sc-39459 from Santa Cruz Biotechnology
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FGF-8 shRNA Plasmid (m) - sc-39459-SH from Santa Cruz Biotechnology
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FGF-8 shRNA (m) Lentiviral Particles - sc-39459-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU000361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31365 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31365 from Sigma-Aldrich
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FGF8 siRNA (Mouse) - CRM1353 from Cohesion Biosciences
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FGF8 - MBS8230348 from MyBioSource
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shRNA set against Mouse FGF8 (NM_010205.2) - SHH294605 from Creative biogene
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Mouse FGF8 siRNA - orb280829 from Biorbyt
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FGF8 shRNA Plasmid (Mouse) - CHM1353 from Cohesion Biosciences
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