Gene Symbol | CHD1L |
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Entrez Gene | 9557 |
Alt Symbol | ALC1, CHDL |
Species | Human |
Gene Type | protein-coding |
Description | chromodomain helicase DNA binding protein 1-like |
Other Description | amplified in liver cancer 1|amplified in liver cancer protein 1|chromodomain-helicase-DNA-binding protein 1-like |
Swissprots | Q96HF7 Q6PK83 A5YM64 B5MDZ7 Q96SP3 Q86XH3 B4DDE1 Q53EZ3 Q9NVV8 Q86WJ1 Q5VXX7 Q9BVJ1 Q6DD94 |
Accessions | CAH72650 EAW50936 EAW50937 EAW50938 Q86WJ1 AF054177 AAC39911 AF537213 AAO49505 AK001342 BAA91637 AK026183 BAB15386 AK027631 BAB55248 AK223496 BAD97216 AK293157 BAG56702 AK297135 BAG59638 AK298424 BAG60647 AK307400 BC001171 AAH01171 BC005038 AAH05038 BC008649 AAH08649 BC043501 AAH43501 BC053354 BC077717 AAH77717 BG195857 CB153921 CN255647 CN255649 CN255654 CR749729 DA007597 DA155685 DA745071 EC452903 EF560738 ABQ59048 KJ534809 AHW56449 R46126 XM_006711638 XP_006711701 XM_006711639 XP_006711702 XR_922001 NM_001256336 NP_001243265 NM_001256337 NP_001243266 NM_001256338 NP_001243267 NM_004284 NP_004275 NM_024568 NP_078844 NR_046070 |
Function | DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. {ECO:0000269|PubMed:18023026, ECO:0000269|PubMed:19661379}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19661379}. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1. |
Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas. {ECO:0000269|PubMed:18023026}. |
CHD1L Antibody Blocking Peptide - LS-E4168 from LifeSpan Bioscience
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CHD1L-Antibody-Center-Blocking-Peptide - BP16423c from Abgent, a WuXi AppTec company
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CHD1L Blocking Peptide - 33R-1859 from Fitzgerald
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CHD1L Blocking Peptide - abx063598 from Abbexa
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MYL4 Human - PRPS-999 from NeoScientific
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CHD1L Blocking Peptide - CBP2404 from Cohesion Biosciences
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Recombinant Human Chromodomain-helicase-DNA-binding protein 1-like(CHD1L) ,partial - CSB-YP803136HU CSB-EP803136HU CSB-BP803136HU CSB-MP803136HU from Cusabio
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CHD1L - TP323499 from Acris Antibodies
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CHD1L Recombinant Protein Antigen - NBP1-89154PEP from Novus Biologicals
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CHD1L Recombinant Protein Antigen - NBP1-89153PEP from Novus Biologicals
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CHD1L Peptide, Human - M34GP03072H from Creative Peptides
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Human CHD1L protein - orb383099 from Biorbyt
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Recombinant Human Chromodomain-helicase-DNA-binding protein 1-like(CHD1L),partial - AP74522 from Signalway Antibody
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Chromodomain-helicase-DNA-binding protein 1-like (CHD1L), Recombinant Protein - MBS9424102 from MyBioSource
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Chromodomain-helicase-DNA-binding protein 1-like (CHD1L), partial, Recombinant Protein - MBS1372427 from MyBioSource
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CHD1L Recombinant Protein (Human) (OPCA04292) - OPCA04292 from Aviva Systems Biology
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Recombinant Human CHD1L Protein (704-897 aa), His-SUMO-tagged - CHD1L-2043H from Creative Biomart
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