ID3

Gene Symbol	ID3
Entrez Gene	3399
Alt Symbol	HEIR-1, bHLHb25
Species	Human
Gene Type	protein-coding
Description	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Other Description	DNA-binding protein inhibitor ID-3|ID-like protein inhibitor HLH 1R21|class B basic helix-loop-helix protein 25|helix-loop-helix protein HEIR-1|inhibitor of differentiation 3
Swissprots	Q02535 O75641 A8K1T8
Accessions	CAA51827 EAW95060 EAW95061 Q02535 A17546 CAA01342 A17548 CAA01343 AK225965 AK290003 BAF82692 BC003107 AAH03107 BM921819 BP193075 BT006791 AAP35437 D28449 BAA05815 DQ892504 ABM83430 DQ895539 ABM86465 DQ895717 ABM86643 X66924 CAA47360 X69111 CAA48862 NM_002167 NP_002158
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}.
Subcellular Location	Nucleus.
Tissue Specificity	Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
Top Pathways	TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ID3 full length protein - ab112307 from Abcam Category Protein Source Wheat germ Species Human

Human ID3 protein fragment - ab114366 from Abcam Category Protein Source Wheat germ Species Human

ID3 Antibody Blocking Peptide - LS-E4770 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ID3 Antibody Blocking Peptide - LS-E5781 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ID3 Antibody Blocking Peptide - LS-E10634 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ID3 Antibody Blocking Peptide - LS-E11309 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ID3 Recombinant Protein - H00003399-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ID3 Protein - H00003399-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ID3-Antibody-N-term-Blocking-Peptide - BP17144a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ID3-Antibody-C-term-Blocking-Peptide - BP18321b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ID3 / BHLHB25 - H00003399-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ID3 / BHLHB25 - H00003399-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ID3 / BHLHB25 - H00003399-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ID3 / BHLHB25 - H00003399-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ID3 fusion protein - ag0588 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ID3 - ID3-28591TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human ID3 - ID3-28926TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human DNA-binding protein inhibitor ID-3(ID3) - CSB-YP010969HU CSB-EP010969HU CSB-BP010969HU CSB-MP010969HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ID3 / BHLHB25 - TP300583 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ID3 Recombinant Protein Antigen - NBP2-47423PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ID3 Peptide, Human - M34GP07394H from Creative Peptides Category Peptide Source Synthetic. Species Human

DNA-binding protein inhibitor ID-3 (ID3), Recombinant Protein - MBS962907 from MyBioSource Category Protein Prices $855.00, $855.00, $1,080.00, $1,080.00, $1,235.00, $1,235.00, $1,695.00, $1,695.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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