ID3

Gene Symbol	ID3
Entrez Gene	3399
Alt Symbol	HEIR-1, bHLHb25
Species	Human
Gene Type	protein-coding
Description	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Other Description	DNA-binding protein inhibitor ID-3|ID-like protein inhibitor HLH 1R21|class B basic helix-loop-helix protein 25|helix-loop-helix protein HEIR-1|inhibitor of differentiation 3
Swissprots	Q02535 O75641 A8K1T8
Accessions	CAA51827 EAW95060 EAW95061 Q02535 A17546 CAA01342 A17548 CAA01343 AK225965 AK290003 BAF82692 BC003107 AAH03107 BM921819 BP193075 BT006791 AAP35437 D28449 BAA05815 DQ892504 ABM83430 DQ895539 ABM86465 DQ895717 ABM86643 X66924 CAA47360 X69111 CAA48862 NM_002167 NP_002158
Function	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}.
Subcellular Location	Nucleus.
Tissue Specificity	Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
Top Pathways	TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Id3 CRISPR/Cas9 KO Plasmid (h) - sc-400944 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 HDR Plasmid (h) - sc-400944-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 Double Nickase Plasmid (h) - sc-400944-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 Double Nickase Plasmid (h2) - sc-400944-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 CRISPR Activation Plasmid (h) - sc-400944-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 CRISPR Activation Plasmid (h2) - sc-400944-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 Lentiviral Activation Particles (h) - sc-400944-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 Lentiviral Activation Particles (h2) - sc-400944-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 siRNA (h) - sc-38002 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id3 shRNA Plasmid (h) - sc-38002-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id3 shRNA (h) Lentiviral Particles - sc-38002-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id3 siRNA (h2) - sc-63297 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id3 shRNA Plasmid (h2) - sc-63297-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Id3 shRNA (h2) Lentiviral Particles - sc-63297-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ID3 RNAi - H00003399-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU023011 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10439 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10439 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12150 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr12150

ID3 siRNA (Human) - CRH2309 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ID3 RNAi - H00003399-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ID3 - MBS8201802 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Id3 CRISPR/Cas9 KO Plasmid (h2) - sc-400944-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Id3 HDR Plasmid (h2) - sc-400944-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human ID3 (NM_002167.4) - SHH316521 from Creative biogene Category siRNA Species Reactivities Human

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