| Gene Symbol |
XYLT1
|
| Entrez Gene |
64131
|
| Alt Symbol |
DBQD2, PXYLT1, XT-I, XT1, XTI, XYLTI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
xylosyltransferase I
|
| Other Description |
O-xylosyltransferase 1|beta-D-xylosyltransferase 1|peptide O-xylosyltransferase 1|xylT-I|xylosyltransferase 1|xylosyltransferase iota
|
| Swissprots |
Q9H1B6 Q86Y38
|
| Accessions |
AIZ49756 AJM90214 EAW50949 Q86Y38 AI524006 AJ277441 CAC16787 AJ539163 CAD62248 AK000198 AL050125 BC036692 BC045778 BC156039 AAI56040 BU620961 BX647541 XM_011522574 XP_011520876 NM_022166 NP_071449
|
| Function |
Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269|PubMed:16571645}; Single- pass type II membrane protein {ECO:0000250}. Secreted {ECO:0000305|PubMed:10383739}. Note=Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle. {ECO:0000269|PubMed:11099377}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|