| Gene Symbol | XYLT1 |
|---|---|
| Entrez Gene | 64131 |
| Alt Symbol | DBQD2, PXYLT1, XT-I, XT1, XTI, XYLTI |
| Species | Human |
| Gene Type | protein-coding |
| Description | xylosyltransferase I |
| Other Description | O-xylosyltransferase 1|beta-D-xylosyltransferase 1|peptide O-xylosyltransferase 1|xylT-I|xylosyltransferase 1|xylosyltransferase iota |
| Swissprots | Q9H1B6 Q86Y38 |
| Accessions | AIZ49756 AJM90214 EAW50949 Q86Y38 AI524006 AJ277441 CAC16787 AJ539163 CAD62248 AK000198 AL050125 BC036692 BC045778 BC156039 AAI56040 BU620961 BX647541 XM_011522574 XP_011520876 NM_022166 NP_071449 |
| Function | Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269|PubMed:16571645}; Single- pass type II membrane protein {ECO:0000250}. Secreted {ECO:0000305|PubMed:10383739}. Note=Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted. |
| Tissue Specificity | Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle. {ECO:0000269|PubMed:11099377}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
XylT-I CRISPR/Cas9 KO Plasmid (h) - sc-404590 from Santa Cruz Biotechnology
|
||||||||
XylT-I HDR Plasmid (h) - sc-404590-HDR from Santa Cruz Biotechnology
|
||||||||
XylT-I Double Nickase Plasmid (h) - sc-404590-NIC from Santa Cruz Biotechnology
|
||||||||
XylT-I Double Nickase Plasmid (h2) - sc-404590-NIC-2 from Santa Cruz Biotechnology
|
||||||||
XylT-I CRISPR Activation Plasmid (h) - sc-404590-ACT from Santa Cruz Biotechnology
|
||||||||
XylT-I CRISPR Activation Plasmid (h2) - sc-404590-ACT-2 from Santa Cruz Biotechnology
|
||||||||
XylT-I Lentiviral Activation Particles (h) - sc-404590-LAC from Santa Cruz Biotechnology
|
||||||||
XylT-I Lentiviral Activation Particles (h2) - sc-404590-LAC-2 from Santa Cruz Biotechnology
|
||||||||
XylT-I siRNA (h) - sc-61817 from Santa Cruz Biotechnology
|
||||||||
XylT-I shRNA Plasmid (h) - sc-61817-SH from Santa Cruz Biotechnology
|
||||||||
XylT-I shRNA (h) Lentiviral Particles - sc-61817-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU037151 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22992 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22992 from Sigma-Aldrich
|
||||||||
XYLT1 siRNA (Human) - CRJ1939 from Cohesion Biosciences
|
||||||||
XYLT1 - MBS8218158 from MyBioSource
|
||||||||
shRNA set against Human XYLT1 (NM_022166.3) - SHH448204 from Creative biogene
|
||||||||
shRNA set against Human XYLT1(NM_022166.3) - SHL139332 from Creative biogene
|
||||||||
Human XYLT1 siRNA - orb272440 from Biorbyt
|
||||||||
XYLT1 shRNA Plasmid (Human) - CHJ1939 from Cohesion Biosciences
|
||||||||
XYLT1 miRNA 3'UTR clone - MiUTR1H-11328 from Creative biogene
|