| Gene Symbol |
DDIT4L
|
| Entrez Gene |
115265
|
| Alt Symbol |
REDD2, Rtp801L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA-damage-inducible transcript 4-like
|
| Other Description |
DNA damage-inducible transcript 4-like protein|HIF-1 responsive protein RTP801-like|REDD-2|homolog of mouse SMHS1|protein regulated in development and DNA damage response 2|regulated in development and DNA damage response 2
|
| Swissprots |
B2R7C3 Q96D03
|
| Accessions |
CAD28403 EAX06119 Q96D03 AK094236 BAC04315 AK312926 BAG35770 AL832277 CAI46176 BC013592 AAH13592 DB208869 HQ447928 ADQ32412 XM_005262721 XP_005262778 NM_145244 NP_660287
|
| Function |
Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. {ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery. {ECO:0000269|PubMed:15308555}.
|