Gene Symbol | DDIT4L |
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Entrez Gene | 115265 |
Alt Symbol | REDD2, Rtp801L |
Species | Human |
Gene Type | protein-coding |
Description | DNA-damage-inducible transcript 4-like |
Other Description | DNA damage-inducible transcript 4-like protein|HIF-1 responsive protein RTP801-like|REDD-2|homolog of mouse SMHS1|protein regulated in development and DNA damage response 2|regulated in development and DNA damage response 2 |
Swissprots | B2R7C3 Q96D03 |
Accessions | CAD28403 EAX06119 Q96D03 AK094236 BAC04315 AK312926 BAG35770 AL832277 CAI46176 BC013592 AAH13592 DB208869 HQ447928 ADQ32412 XM_005262721 XP_005262778 NM_145244 NP_660287 |
Function | Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. {ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery. {ECO:0000269|PubMed:15308555}. |
REDD-2 CRISPR/Cas9 KO Plasmid (h) - sc-416729 from Santa Cruz Biotechnology
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REDD-2 HDR Plasmid (h) - sc-416729-HDR from Santa Cruz Biotechnology
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REDD-2 Double Nickase Plasmid (h) - sc-416729-NIC from Santa Cruz Biotechnology
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REDD-2 Double Nickase Plasmid (h2) - sc-416729-NIC-2 from Santa Cruz Biotechnology
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REDD-2 CRISPR Activation Plasmid (h) - sc-416729-ACT from Santa Cruz Biotechnology
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REDD-2 CRISPR Activation Plasmid (h2) - sc-416729-ACT-2 from Santa Cruz Biotechnology
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REDD-2 Lentiviral Activation Particles (h) - sc-416729-LAC from Santa Cruz Biotechnology
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REDD-2 Lentiviral Activation Particles (h2) - sc-416729-LAC-2 from Santa Cruz Biotechnology
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REDD-2 siRNA (h) - sc-88956 from Santa Cruz Biotechnology
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REDD-2 shRNA Plasmid (h) - sc-88956-SH from Santa Cruz Biotechnology
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REDD-2 shRNA (h) Lentiviral Particles - sc-88956-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU126071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7027 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7027 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10371 from Sigma-Aldrich
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DDIT4L siRNA (Human) - CRJ4436 from Cohesion Biosciences
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DDIT4L - MBS8214141 from MyBioSource
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shRNA set against Human DDIT4L (NM_145244.3) - SHH275677 from Creative biogene
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Human DDIT4L siRNA - orb274937 from Biorbyt
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DDIT4L shRNA Plasmid (Human) - CHJ4436 from Cohesion Biosciences
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DDIT4L miRNA 3'UTR clone - MiUTR3H-09427 from Creative biogene
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