Gene Symbol | DDIT4L |
---|---|
Entrez Gene | 115265 |
Alt Symbol | REDD2, Rtp801L |
Species | Human |
Gene Type | protein-coding |
Description | DNA-damage-inducible transcript 4-like |
Other Description | DNA damage-inducible transcript 4-like protein|HIF-1 responsive protein RTP801-like|REDD-2|homolog of mouse SMHS1|protein regulated in development and DNA damage response 2|regulated in development and DNA damage response 2 |
Swissprots | B2R7C3 Q96D03 |
Accessions | CAD28403 EAX06119 Q96D03 AK094236 BAC04315 AK312926 BAG35770 AL832277 CAI46176 BC013592 AAH13592 DB208869 HQ447928 ADQ32412 XM_005262721 XP_005262778 NM_145244 NP_660287 |
Function | Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. {ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery. {ECO:0000269|PubMed:15308555}. |