PDE4D

Gene Symbol	PDE4D
Entrez Gene	5144
Alt Symbol	ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 4D, cAMP-specific
Other Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D|cAMP-specific phosphodiesterase PDE4D6|phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Swissprots	Q8IVD3 Q8IVD2 Q9HCX7 Q13551 Q96HL4 Q8IVA9 Q13550 Q08499 Q8IV84 Q7Z2L8 O43433 Q13549
Accessions	EAW54982 EAW54983 EAW54984 EAW54985 EAW54986 EAW54987 EAW54988 EAW54989 EAW54990 EAW54991 EAW54992 Q08499 AF012073 AAC00069 AF012074 AAC00070 AF536975 AAN10117 AF536976 AAN10118 AF536977 AAN10119 AF536980 AJ250852 CAC03756 AJ250854 CAC03757 AJ250855 CAC03758 AK307363 AY245866 AAP75760 AY245867 AAP75761 AY388960 AAQ90404 BC008390 AAH08390 BC036319 AAH36319 BF197530 BI492585 BT007398 AAP36062 BX648604 DB230503 JF432192 ADZ15409 L20970 AAA03592 U02882 AAC13745 U50157 AAA97890 U50158 AAA97891 U50159 AAA97892 U79571 AAC51928 XM_005248537 XP_005248594 XM_005248538 XP_005248595 XM_011543469 XP_011541771 XM_011543470 XP_011541772 XM_011543471 XP_011541773 XM_011543472 XP_011541774 XM_011543473 XP_011541775 XM_011543474 XP_011541776 XM_011543475 XP_011541777 XM_011543476 XP_011541778 XM_011543477 XP_011541779 XM_011543478 XP_011541780 XM_011543479 XP_011541781 NM_001104631 NP_001098101 NM_001165899 NP_001159371 NM_001197218 NP_001184147 NM_001197219 NP_001184148 NM_001197220 NP_001184149 NM_001197221 NP_001184150 NM_001197222 NP_001184151 NM_001197223 NP_001184152 NM_006203 NP_006194
Function	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:14500724}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells. {ECO:0000250}.
Tissue Specificity	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. {ECO:0000269|PubMed:12834813, ECO:0000269|PubMed:17244609}.
Top Pathways	Morphine addiction, cAMP signaling pathway, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDE4D-Over-expression-Lysate - LY13012a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PDE4D overexpression lysate - LY401868 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PDE4D overexpression lysate - LY434324 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PDE4D overexpression lysate - LY434368 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PDE4D 293 Cell Lysate - 401664 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg Species Drosophila

Phosphodiesterase 4D Overexpression Lysate (Native) - NBL1-14223 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PDE4D Over-expression Lysate Product - GWB-110EE5 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human PDE4D Knockdown Stable Cell Line - CSC-DC011506 from Creative biogene Category Cell Line Species Human

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