PDE4D

Gene Symbol	PDE4D
Entrez Gene	5144
Alt Symbol	ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 4D, cAMP-specific
Other Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D|cAMP-specific phosphodiesterase PDE4D6|phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Swissprots	Q8IVD3 Q8IVD2 Q9HCX7 Q13551 Q96HL4 Q8IVA9 Q13550 Q08499 Q8IV84 Q7Z2L8 O43433 Q13549
Accessions	EAW54982 EAW54983 EAW54984 EAW54985 EAW54986 EAW54987 EAW54988 EAW54989 EAW54990 EAW54991 EAW54992 Q08499 AF012073 AAC00069 AF012074 AAC00070 AF536975 AAN10117 AF536976 AAN10118 AF536977 AAN10119 AF536980 AJ250852 CAC03756 AJ250854 CAC03757 AJ250855 CAC03758 AK307363 AY245866 AAP75760 AY245867 AAP75761 AY388960 AAQ90404 BC008390 AAH08390 BC036319 AAH36319 BF197530 BI492585 BT007398 AAP36062 BX648604 DB230503 JF432192 ADZ15409 L20970 AAA03592 U02882 AAC13745 U50157 AAA97890 U50158 AAA97891 U50159 AAA97892 U79571 AAC51928 XM_005248537 XP_005248594 XM_005248538 XP_005248595 XM_011543469 XP_011541771 XM_011543470 XP_011541772 XM_011543471 XP_011541773 XM_011543472 XP_011541774 XM_011543473 XP_011541775 XM_011543474 XP_011541776 XM_011543475 XP_011541777 XM_011543476 XP_011541778 XM_011543477 XP_011541779 XM_011543478 XP_011541780 XM_011543479 XP_011541781 NM_001104631 NP_001098101 NM_001165899 NP_001159371 NM_001197218 NP_001184147 NM_001197219 NP_001184148 NM_001197220 NP_001184149 NM_001197221 NP_001184150 NM_001197222 NP_001184151 NM_001197223 NP_001184152 NM_006203 NP_006194
Function	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:14500724}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells. {ECO:0000250}.
Tissue Specificity	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. {ECO:0000269|PubMed:12834813, ECO:0000269|PubMed:17244609}.
Top Pathways	Morphine addiction, cAMP signaling pathway, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human hPDE4D2 full length protein - ab80335 from Abcam Category Protein Prices $532.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PDE4D full length protein - ab198456 from Abcam Category Protein Prices $1,250.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PDE4D protein fragment - ab125534 from Abcam Category Protein Prices $302.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PDE4D3 full length protein - ab80332 from Abcam Category Protein Prices $466.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active rat PDE4D full length protein - ab198442 from Abcam Category Protein Prices $1,250.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Rat

Human PDE4D full length protein - ab159074 from Abcam Category Protein Source Wheat germ Species Human

Human PDE4D peptide - ab97991 from Abcam Category Peptide

Human PDE4D protein fragment - ab159075 from Abcam Category Protein Source Wheat germ Species Human

PDE4D peptide - ab169991 from Abcam Category Peptide

PDE4D Antibody Blocking Peptide - LS-E20609 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE4D Antibody Blocking Peptide - LS-E26225 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE4D Antibody Blocking Peptide - LS-E26004 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Phosphodiesterase 4D Protein - H00005144-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Phosphodiesterase 4D Protein - H00005144-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDE4D blocking peptide - GTX89423-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PDE4D3 blocking peptide - GTX89159-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Rat

Pde4d Blocking Peptide - 33R-7069 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDE4D Peptide - AC21-0832-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PDE4D Peptide - AC21-1056-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PDE4D - H00005144-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

PDE4D - H00005144-P01-10 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source in vitro transl. Species Human

PDE4D - H00005144-P01-25 from Acris Antibodies Category Protein Prices $460.00 Sizes 25 µg Source in vitro transl. Species Human

PDE4D - H00005144-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PDE4D - H00005144-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PDE4D control peptide - AP10228CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

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