USP8

Gene Symbol	USP8
Entrez Gene	9101
Alt Symbol	HumORF8, SPG59, UBPY
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 8
Other Description	deubiquitinating enzyme 8|ubiquitin carboxyl-terminal hydrolase 8|ubiquitin isopeptidase Y|ubiquitin thiolesterase 8|ubiquitin-specific-processing protease 8
Swissprots	B4DKA8 Q86VA0 Q8IWI7 Q7Z3U2 P40818 Q2TB31
Accessions	EAW77399 EAW77400 EAW77401 EAW77402 P40818 AA399951 AA399952 AA773713 AI276208 AK091775 BAG52415 AK292400 BAF85089 AK296480 BAG59120 AK300590 BAG62288 BC015545 AAH15545 BC026954 AAH26954 BC038801 AAH38801 BC051345 AAH51345 BC062694 BC092443 BC110590 AAI10591 BM751645 BX537420 CAD97662 CA312140 D29956 BAA06225 DA112964 XM_006720761 XP_006720824 XM_006720762 XP_006720825 XM_011522193 XP_011520495 XM_011522194 XP_011520496 NM_001128610 NP_001122082 NM_001283049 NP_001269978 NM_005154 NP_005145 NM_001128611
Function	Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with t
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}. Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rabbit anti-USP8 Antibody, Affinity Purified - PLA0272 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human USP8 / UBPY ELISA Kit (Sandwich ELISA) - LS-F7098 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.101 ng/ml Range 0.313-20 ng/ml

Ubiquitin Specific Peptidase 8 (USP8), Human, ELISA Kit - SEF148Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.101ng/mL Range 0.312-20ng/mL

Ubiquitin Specific Peptidase 8, USP8, Human, ELISA Kit - E-EL-H2389 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Ubiquitin Specific Peptidase 8, USP8, Rabbit, ELISA Kit - E-EL-RB0105 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Specific Peptidase 8, USP8, Chicken, ELISA Kit - E-EL-Ch0830 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Ubiquitin Specific Peptidase 8, USP8, Porcine, ELISA Kit - E-EL-P0737 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Specific Peptidase 8, USP8, Guinea Pig, ELISA Kit - E-EL-GP0279 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ubiquitin Specific Peptidase 8, USP8, Monkey, ELISA Kit - E-EL-MK1804 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ubiquitin Specific Peptidase 8 (USP8), ELISA Kit - MBS9315077 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Specific Peptidase 8 (USP8), ELISA Kit - MBS2021146 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.101ng/mL. Range 0.313-20ng/mL

USP8, ELISA Kit - MBS2502961 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

USP8, ELISA Kit - MBS2500176 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

USP8, ELISA Kit - MBS2501010 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

USP8, ELISA Kit - MBS2506391 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

USP8, ELISA Kit - MBS2507180 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

USP8, ELISA Kit - MBS2510523 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Human USP8(Ubiquitin Specific Peptidase 8) ELISA Kit - E-EL-H2389 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human USP8 (Ubiquitin Specific Peptidase 8) CLIA Kit - E-CL-H1394 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

Ubiquitin Specific Peptidase 8, ELISA Kit - MBS096768 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Specific Peptidase 8, ELISA Kit - MBS058881 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Specific Peptidase 8, ELISA Kit - MBS090134 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Specific Peptidase 8, ELISA Kit - MBS054823 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Specific Peptidase 8, ELISA Kit - MBS075053 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ubiquitin Specific Peptidase 8, ELISA Kit - MBS077873 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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