| Gene Symbol | USP8 |
|---|---|
| Entrez Gene | 9101 |
| Alt Symbol | HumORF8, SPG59, UBPY |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin specific peptidase 8 |
| Other Description | deubiquitinating enzyme 8|ubiquitin carboxyl-terminal hydrolase 8|ubiquitin isopeptidase Y|ubiquitin thiolesterase 8|ubiquitin-specific-processing protease 8 |
| Swissprots | B4DKA8 Q86VA0 Q8IWI7 Q7Z3U2 P40818 Q2TB31 |
| Accessions | EAW77399 EAW77400 EAW77401 EAW77402 P40818 AA399951 AA399952 AA773713 AI276208 AK091775 BAG52415 AK292400 BAF85089 AK296480 BAG59120 AK300590 BAG62288 BC015545 AAH15545 BC026954 AAH26954 BC038801 AAH38801 BC051345 AAH51345 BC062694 BC092443 BC110590 AAI10591 BM751645 BX537420 CAD97662 CA312140 D29956 BAA06225 DA112964 XM_006720761 XP_006720824 XM_006720762 XP_006720825 XM_011522193 XP_011520495 XM_011522194 XP_011520496 NM_001128610 NP_001122082 NM_001283049 NP_001269978 NM_005154 NP_005145 NM_001128611 |
| Function | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with t |
| Subcellular Location | Cytoplasm. Nucleus {ECO:0000250}. Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. |
| Top Pathways | Endocytosis |