USP8

Gene Symbol	USP8
Entrez Gene	9101
Alt Symbol	HumORF8, SPG59, UBPY
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 8
Other Description	deubiquitinating enzyme 8|ubiquitin carboxyl-terminal hydrolase 8|ubiquitin isopeptidase Y|ubiquitin thiolesterase 8|ubiquitin-specific-processing protease 8
Swissprots	B4DKA8 Q86VA0 Q8IWI7 Q7Z3U2 P40818 Q2TB31
Accessions	EAW77399 EAW77400 EAW77401 EAW77402 P40818 AA399951 AA399952 AA773713 AI276208 AK091775 BAG52415 AK292400 BAF85089 AK296480 BAG59120 AK300590 BAG62288 BC015545 AAH15545 BC026954 AAH26954 BC038801 AAH38801 BC051345 AAH51345 BC062694 BC092443 BC110590 AAI10591 BM751645 BX537420 CAD97662 CA312140 D29956 BAA06225 DA112964 XM_006720761 XP_006720824 XM_006720762 XP_006720825 XM_011522193 XP_011520495 XM_011522194 XP_011520496 NM_001128610 NP_001122082 NM_001283049 NP_001269978 NM_005154 NP_005145 NM_001128611
Function	Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with t
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}. Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human UBPY/USP8 full length protein - ab198666 from Abcam Category Protein Prices $1,187.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Active human UBPY/USP8 full length protein - ab125744 from Abcam Category Protein Source E. coli Species Human

Active human UBPY/USP8 full length protein - ab188703 from Abcam Category Protein Prices $717.00 Sizes 25 µg Source Baculovirus infected sf9 cells Species Human

UBPY/USP8 protein (His-DHFR tag) - ab127607 from Abcam Category Protein Source E. coli Species Human

USP8 / UBPY Antibody Blocking Peptide - LS-E21687 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP8 / UBPY Antibody Blocking Peptide - LS-E21686 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP8 / UBPY Antibody Blocking Peptide - LS-E6883 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP8 / UBPY Antibody Blocking Peptide - LS-E6884 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP8 / UBPY Antibody Blocking Peptide - LS-E6885 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBPY/USP8 Peptide - P0931 from Novus Biologicals Category Peptide Species Human

UBPY/USP8 Peptide - P0929 from Novus Biologicals Category Peptide Species Human

UBPY/USP8 Peptide - P0928 from Novus Biologicals Category Peptide Species Human

USP8-UBPY-Antibody-C-term-Blocking-peptide - BP2138b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP8-UBPY-Antibody-C-term-Blocking-peptide - BP2137b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP8-Antibody-N-term-Blocking-Peptide - BP2137a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-USP8, CF - E-520-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 9 (baculovirus)-derived, Contains an N-terminal 6-His tag

USP8 Blocking Peptide - 33R-2843 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP8 fusion protein - ag17977 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

USP8 fusion protein - ag16602 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

USP8 (UBPY) Active Human Recombinant Protein - GWB-FD384C from Genway Biotech Category Protein Prices $566.00 Sizes 50 µg Species Human

Recombinant Human USP8, FLAG-tagged - USP8-86H from Creative Biomart Category Protein Source Sf9 cell Species Human

Recombinant Human USP8 - USP8-127H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human USP8, His & SUMO-tagged - USP8-161H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human USP8, His-tagged - USP8-162H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Ubiquitin Specific Peptidase 8 (USP8) - RPF148Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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