| Gene Symbol |
PAOX
|
| Entrez Gene |
196743
|
| Alt Symbol |
PAO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polyamine oxidase (exo-N4-amino)
|
| Other Description |
peroxisomal N(1)-acetyl-spermine/spermidine oxidase|peroxisomal N1-acetyl-spermine/spermidine oxidase
|
| Swissprots |
Q8N555 Q86WP9 Q6QHG3 Q6QHG4 Q5VWY0 Q6QHG1 Q6QHF9 Q6QHG0 Q6QHG6 Q6QHF8 Q8NCX3 D3DXI6 Q6QHF6 Q6QHF5 Q6QHG5 Q6QHG2 Q6QHF7
|
| Accessions |
EAW61340 EAW61341 EAW61342 EAW61343 EAW61344 EAW61345 EAW61346 EAW61347 Q6QHF9 AA280165 AF226657 AAN40706 AF312698 AAO63265 AK124186 AK128001 BAG54616 AL834535 CAD39191 AY358418 AAQ88784 AY541513 AAS64373 AY541514 AAS64374 AY541515 AAS64375 AY541516 AAS64376 AY541517 AAS64377 AY541518 AAS64378 AY541519 AAS64379 AY541520 AAS64380 AY541521 AAS64381 AY541522 AAS64382 AY541523 AAS64383 AY541524 AAS64384 BC032778 AAH32778 BE646315 DQ891313 ABM82239 DQ893351 ABM84277 DQ894497 ABM85423 DQ896670 ABM87669 NM_207125 NM_207126 NM_207129 NM_152911 NP_690875 NM_207127 NP_997010 NM_207128 NP_997011 NR_109763 NR_109764 NR_109765 NR_109766
|
| Function |
Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
|
| Subcellular Location |
Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. {ECO:0000269|PubMed:12477380}.
|
| Top Pathways |
Peroxisome
|