BAX

Gene Symbol BAX
Entrez Gene 581
Alt Symbol BCL2L4
Species Human
Gene Type protein-coding
Description BCL2-associated X protein
Other Description BCL2-associated X protein omega|Baxdelta2G9|Baxdelta2G9omega|Baxdelta2omega|apoptosis regulator BAX|bcl-2-like protein 4|bcl2-L-4
Swissprots Q9NYG7 Q8WZ49 Q07814 P55269 Q9UCZ7 Q07815 Q9UCZ6 Q07812 Q9UQD6 Q9NR76 A8K4W1
Accessions AAD01415 AAD01416 AAL73333 AAO22992 EAW52415 EAW52416 EAW52417 EAW52418 EAW52419 EAW52420 EAW52421 Q07812 AF007826 AAD22706 AF247393 AAF71267 AF250190 AAF82094 AI565203 AJ417988 CAD10744 AJ586909 CAE52909 AJ586910 CAE52910 AK291076 BAF83765 BC014175 AAH14175 BE396495 BM673184 BM706954 CN281003 HQ889830 ADZ05507 JX524562 AFU81108 KF830846 AIO10778 KF830847 AIO10779 KF830848 AIO10780 L22473 AAA03619 L22474 AAA03620 L22475 AAA03621 T29044 U19599 AAC50142 XM_006723314 XP_006723377 XM_011527191 XP_011525493 NM_001291428 NP_001278357 NM_001291429 NP_001278358 NM_001291430 NP_001278359 NM_001291431 NP_001278360 NM_004324 NP_004315 NM_138761 NP_620116 NM_138763 NP_620118 NM_138764 NP_620119 NR_027882 NM_138762
Function Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}.
Subcellular Location Isoform Gamma: Cytoplasm.
Tissue Specificity Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11912183}.
Top Pathways Viral carcinogenesis, Sphingolipid signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Apoptosis, Tuberculosis

Bax (D2E11) Rabbit mAb - 5023 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2E11
Western blot analysis of extracts from various cell lines using Bax (D2E11) Rabbit mAb. Brimmel et al. demonstated that Jurkat cells lack Bax protein expression (10).

Bax Antibody - 2772 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 (human), COS (monkey), L929 (mouse) and PC12 (rat) cells, using Bax Antibody.

Bax Antibody - 2774 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293, HT-1080 and Raji cell lines using Bax Antibody #2772 (left) and Bax Antibody #2774 (right).

Bax (2D2) - sc-20067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bax (2D2): sc-20067. Western blot analysis of Bax expression in CCRF-CEM (A), BJAB (B), Ramos (C) and COLO 320DM (D) whole cell lysates.

Bax (Δ 21) - sc-6236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bax (Δ 21): sc-6236. Western blot analysis of Bax expression in RAW 264.7 whole cell lysate.

Bax (6A7) - sc-23959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bax (6A7): sc-23959. Western blot analysis of Bax expression in RAW 264.7 whole cell lysate.

Bax (B-9) - sc-7480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bax (B-9): sc-7480. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing membrane and cytoplasmic localization.

Bax (N-20) - sc-493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bax (N-20): sc-493. Western blot analysis of Bax expression in RAW 264.7 (A) and Jurkat (B) whole cell lysates.

Bax (P-19) - sc-526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Bax expression in Jurkat (A), HuT 78 (B), Ramos (C) and BJAB (D) whole cell lysates. Antibodies tested include Bax (P-19): sc-526 (A,B) and Bax (B-9): sc-7480 (C,D).

Bax (YTH6A7) - sc-80658 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bax (YTH6A7): sc-80658. Western blot analysis of Bax expression in non-transfected 293T: sc-117752 (A), mouse Bax transfected 293T: sc-126476 (B) and HuT 78 (C) whole cell lysates.

Bax (6D149) - sc-70405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Bax (4H32) - sc-70407 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Bax (6D150) - sc-70408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bax (6D150): sc-70408. Western blot analysis of Bax expression in non-transfected 293T: sc-117752 (A), mouse Bax transfected 293T: sc-126476 (B) and HuT 78 (C) whole cell lysates.

Bax (SPM336) - sc-65532 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bax (SPM336): sc-65532. Western blot analysis of Bax expression in SW480 (A), HuT 78 (B), Ramos (C), BJAB (D) and MDA-MB-231 (E) whole cell lysates.

Baxβ (K-17) - sc-20287 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Baxβ (S-18) - sc-20288 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Bax (phospho S184) antibody - ab111391 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue, staining Bax (phospho S184) with ab111391 at 1/50 dilution. The picture on the right is treated with the synthesized peptide.

Anti-Bax (phospho T167) antibody - ab111365 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cells, staining Bax with ab111365 at 1/100 dilution. The image on the right is treated with the synthesized peptide.

Anti-Bax (phospho T167) antibody - ab192819 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of paraffin-embedded, methanol-fixed A549 cells labeling Bax with ab192819 at a 1/100 dilution.  The image on the right has been pre-incubated with synthesized peptide.

Anti-Bax antibody - ab7977 from Abcam

Prices $400.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
ab7977 staining Bax in SK-N-SH cells treated with isobavachalcone (ab141168), by ICC/IF. Increase of Bax expression correlates with increased concentration of isobavachalcone, as described in literature.The cells were incubated at 37°C for 6h in media containing different concentrations of ab141168 (isobavachalcone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (5 μg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Anti-Bax antibody - ab10813 from Abcam

Prices $394.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunofluroescence analysis of HeLa cells, staining Bax with ab10813 (green).Cells were fixed in paraformaldehyde, permeabilised with 0.5%Triton X-100/PBS and counterstained with DAPi in order to highlight the nucleus. Please refer to abreview for further experimental details.See Abreview

Anti-Bax antibody - ab69643 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HUVEC cells, staining Bax with ab69643 at 1/100 dilution.

Anti-Bax antibody - ab53154 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cells, using ab53154 at 1/100 dilution. The picture on the right is treated with the synthesized peptide.

Anti-Bax antibody - ab33020 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Bax antibody - ab54829 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Immunofluorescence analysis of HeLa cells, staining Bax with ab54829 at 10 µg/ml
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