BAX

Gene Symbol	BAX
Entrez Gene	581
Alt Symbol	BCL2L4
Species	Human
Gene Type	protein-coding
Description	BCL2-associated X protein
Other Description	BCL2-associated X protein omega|Baxdelta2G9|Baxdelta2G9omega|Baxdelta2omega|apoptosis regulator BAX|bcl-2-like protein 4|bcl2-L-4
Swissprots	Q9NYG7 Q8WZ49 Q07814 P55269 Q9UCZ7 Q07815 Q9UCZ6 Q07812 Q9UQD6 Q9NR76 A8K4W1
Accessions	AAD01415 AAD01416 AAL73333 AAO22992 EAW52415 EAW52416 EAW52417 EAW52418 EAW52419 EAW52420 EAW52421 Q07812 AF007826 AAD22706 AF247393 AAF71267 AF250190 AAF82094 AI565203 AJ417988 CAD10744 AJ586909 CAE52909 AJ586910 CAE52910 AK291076 BAF83765 BC014175 AAH14175 BE396495 BM673184 BM706954 CN281003 HQ889830 ADZ05507 JX524562 AFU81108 KF830846 AIO10778 KF830847 AIO10779 KF830848 AIO10780 L22473 AAA03619 L22474 AAA03620 L22475 AAA03621 T29044 U19599 AAC50142 XM_006723314 XP_006723377 XM_011527191 XP_011525493 NM_001291428 NP_001278357 NM_001291429 NP_001278358 NM_001291430 NP_001278359 NM_001291431 NP_001278360 NM_004324 NP_004315 NM_138761 NP_620116 NM_138763 NP_620118 NM_138764 NP_620119 NR_027882 NM_138762
Function	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}.
Subcellular Location	Isoform Gamma: Cytoplasm.
Tissue Specificity	Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11912183}.
Top Pathways	Viral carcinogenesis, Sphingolipid signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Apoptosis, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Bax peptide - ab188834 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Bax full length protein - ab85157 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source E. coli Species Human

Human Bax peptide - ab7987 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human Bax protein fragment - ab173026 from Abcam Category Protein Prices $210.00 Sizes 10 µg Source E. coli Species Human

Mouse Bax protein fragment - ab59854 from Abcam Category Protein Source E. coli Species Mouse

Mouse Bax protein fragment - ab73697 from Abcam Category Protein Source E. coli Species Mouse

BAX Antibody Blocking Peptide - LS-E2127 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAX Antibody Blocking Peptide - LS-E2275 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAX Antibody Blocking Peptide - LS-E5952 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAX Antibody Blocking Peptide - LS-E10534 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAX Antibody Blocking Peptide - LS-E30078 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BAX Antibody Blocking Peptide - LS-E21541 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAX Antibody Blocking Peptide - LS-E21542 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Bax Protein - H00000581-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Bax Protein - H00000581-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Bax Blocking Peptide - NBP1-77151PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Bax-Antibody-BH3-Domain-Specific-Blocking-peptide - BP1302a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BAX-Antibody-N-term-Blocking-Peptide - BP13211a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bax-Antibody-Center-Blocking-peptide - BP18517a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bax-BH3-58-71 - SP2297b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 5 mg

Bax-BH3 - SP2291b from Abgent, a WuXi AppTec company Category Peptide Prices $350.00 Sizes 5 mg

Bax-H3-71-86-Helix-3-71-86 - SP2196b from Abgent, a WuXi AppTec company Category Peptide Prices $385.00 Sizes 5 mg

Bax-H3-71-86-Helix-3-71-86 - SP2196a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Bax-H2-H3-53-86-Helix-2-3 - SP2188b from Abgent, a WuXi AppTec company Category Peptide Prices $279.00 Sizes 1 mg

Bax-H2-H3-53-86-Helix-2-3 - SP2188a from Abgent, a WuXi AppTec company Category Peptide Prices $155.00 Sizes 500 µg

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