Gene Symbol | BAX |
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Entrez Gene | 581 |
Alt Symbol | BCL2L4 |
Species | Human |
Gene Type | protein-coding |
Description | BCL2-associated X protein |
Other Description | BCL2-associated X protein omega|Baxdelta2G9|Baxdelta2G9omega|Baxdelta2omega|apoptosis regulator BAX|bcl-2-like protein 4|bcl2-L-4 |
Swissprots | Q9NYG7 Q8WZ49 Q07814 P55269 Q9UCZ7 Q07815 Q9UCZ6 Q07812 Q9UQD6 Q9NR76 A8K4W1 |
Accessions | AAD01415 AAD01416 AAL73333 AAO22992 EAW52415 EAW52416 EAW52417 EAW52418 EAW52419 EAW52420 EAW52421 Q07812 AF007826 AAD22706 AF247393 AAF71267 AF250190 AAF82094 AI565203 AJ417988 CAD10744 AJ586909 CAE52909 AJ586910 CAE52910 AK291076 BAF83765 BC014175 AAH14175 BE396495 BM673184 BM706954 CN281003 HQ889830 ADZ05507 JX524562 AFU81108 KF830846 AIO10778 KF830847 AIO10779 KF830848 AIO10780 L22473 AAA03619 L22474 AAA03620 L22475 AAA03621 T29044 U19599 AAC50142 XM_006723314 XP_006723377 XM_011527191 XP_011525493 NM_001291428 NP_001278357 NM_001291429 NP_001278358 NM_001291430 NP_001278359 NM_001291431 NP_001278360 NM_004324 NP_004315 NM_138761 NP_620116 NM_138763 NP_620118 NM_138764 NP_620119 NR_027882 NM_138762 |
Function | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}. |
Subcellular Location | Isoform Gamma: Cytoplasm. |
Tissue Specificity | Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11912183}. |
Top Pathways | Viral carcinogenesis, Sphingolipid signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Apoptosis, Tuberculosis |
Bax ELISA Kit - ab133048 from Abcam
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Bax Human SimpleStep ELISAâ„¢ Kit - ab199080 from Abcam
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Human BAX ELISA Kit (Sandwich ELISA) - LS-F4142 from LifeSpan Bioscience
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Rat BAX ELISA Kit (Sandwich ELISA) - LS-F5064 from LifeSpan Bioscience
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Mouse/Human/Rat BAX ELISA Kit (Cell-Based ELISA) - LS-F1820 from LifeSpan Bioscience
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Mouse BAX ELISA Kit (Sandwich ELISA) - LS-F8604 from LifeSpan Bioscience
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Bovine BAX ELISA Kit (Sandwich ELISA) - LS-F8822 from LifeSpan Bioscience
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Rat BAX ELISA Kit (Sandwich ELISA) - LS-F10915 from LifeSpan Bioscience
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Bovine BAX ELISA Kit (Sandwich ELISA) - LS-F10916 from LifeSpan Bioscience
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Human Total Bax-alpha DuoSet IC ELISA - DYC820-2 from R&D Systems
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Human Total Bax-alpha DuoSet IC, 5 Plate - DYC820-5 from R&D Systems
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Human Bax ELISA kit - 55R-IB09623 from Fitzgerald
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Human Bax ELISA Kit - abx150790 from Abbexa
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Apoptosis regulator BAX, BAX, Human, ELISA Kit - E1343h from ARP American Research Products
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Apoptosis regulator BAX, Human, ELISA Kit - CSB-E09344h from ARP American Research Products
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Apoptosis regulator BAX, Human, ELISA Kit - E01A1782 from ARP American Research Products
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Bcl-2 Associated X Protein, Bax, Human, ELISA Kit - E-EL-H0562 from ARP American Research Products
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Bax, Human, ELISA - IB09623 from ARP American Research Products
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Bcl2 Associated X Protein (Bax), Human, ELISA Kit - SEB343Hu from ARP American Research Products
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Bcl-2 Associated X Protein, Bax, Mouse, ELISA Kit - E-EL-M0178 from ARP American Research Products
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BCL-2 Associated X Protein, BAX, Rat, ELISA Kit - E-EL-R0098 from ARP American Research Products
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Bcl-2 Associated X Protein, Bax, Rabbit, ELISA Kit - E-EL-RB1599 from ARP American Research Products
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Bcl-2 Associated X Protein, Bax, Chicken, ELISA Kit - E-EL-Ch1023 from ARP American Research Products
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Bcl-2 Associated X Protein, Bax, Porcine, ELISA Kit - E-EL-P1049 from ARP American Research Products
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Bcl-2 Associated X Protein, Bax, Guinea Pig, ELISA Kit - E-EL-GP0105 from ARP American Research Products
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