| Gene Symbol |
UPK1A
|
| Entrez Gene |
11045
|
| Alt Symbol |
TSPAN21, UP1A, UPIA, UPKA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
uroplakin 1A
|
| Other Description |
tetraspanin-21|tspan-21|uroplakin Ia|uroplakin-1a
|
| Swissprots |
Q3KNU5 Q3KNU6 O00322
|
| Accessions |
AAB57631 AAB62736 O00322 AA548647 AF085807 AAC34887 BC107097 AAI07098 BC107098 AAI07099 HY263470 NM_001281443 NP_001268372 NM_007000 NP_008931
|
| Function |
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies. {ECO:0000269|PubMed:15913809, ECO:0000269|PubMed:9846985}.
|
