| Gene Symbol |
SNX5
|
| Entrez Gene |
27131
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sorting nexin 5
|
| Other Description |
sorting nexin-5
|
| Swissprots |
B7ZKN3 Q52LC4 D3DW26 Q7KZN0 Q9BWP0 Q9Y5X3
|
| Accessions |
EAX10263 EAX10264 EAX10265 EAX10266 EAX10267 EAX10268 Q9Y5X3 AF121855 AAD27828 AK001793 BAA91914 AK026227 AK054634 AK123903 BAG53980 AK129505 AK223308 BAD97028 AK296947 BAH12462 AK308017 AL832967 AW470866 BC000100 BC002724 BC062638 AAH62638 BC073171 BC093623 AAH93623 BC093980 AAH93980 BC143274 AAI43275 BT007191 AAP35855 DA567854 DB118420 NM_001282454 NP_001269383 NM_014426 NP_055241 NM_152227 NP_689413
|
| Function |
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved
|
| Subcellular Location |
Endosome {ECO:0000269|PubMed:11485546}. Early endosome {ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:24610942}. Early endosome membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:18854019}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. {ECO:0000269|PubMed:15561769, ECO:0000269|PubMed:16968745, ECO:0000269|PubMed:21048941}.
|
![Western Blot: SNX5 Overexpression Lysate (Adult Normal) [NBL1-16318] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SNX5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1572_SNX5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16318-img0002.jpg)