SNX5

Gene Symbol	SNX5
Entrez Gene	27131
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	sorting nexin 5
Other Description	sorting nexin-5
Swissprots	B7ZKN3 Q52LC4 D3DW26 Q7KZN0 Q9BWP0 Q9Y5X3
Accessions	EAX10263 EAX10264 EAX10265 EAX10266 EAX10267 EAX10268 Q9Y5X3 AF121855 AAD27828 AK001793 BAA91914 AK026227 AK054634 AK123903 BAG53980 AK129505 AK223308 BAD97028 AK296947 BAH12462 AK308017 AL832967 AW470866 BC000100 BC002724 BC062638 AAH62638 BC073171 BC093623 AAH93623 BC093980 AAH93980 BC143274 AAI43275 BT007191 AAP35855 DA567854 DB118420 NM_001282454 NP_001269383 NM_014426 NP_055241 NM_152227 NP_689413
Function	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved
Subcellular Location	Endosome {ECO:0000269|PubMed:11485546}. Early endosome {ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:24610942}. Early endosome membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:18854019}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. {ECO:0000269|PubMed:15561769, ECO:0000269|PubMed:16968745, ECO:0000269|PubMed:21048941}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SNX5 (D-18) - sc-10625 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX5 (H-40) - sc-50374 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SNX5 (C-15) - sc-10626 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SNX5 antibody - ab153880 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SNX5 antibody [EPR14358] - ab180520 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14358

Anti-SNX5 antibody [EPR14358-10] - ab183719 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14358-10

Anti-SNX5 Antibody (aa43-70) - LS-C203877 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNX5 Antibody (aa31-80) - LS-C146278 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNX5 Antibody (aa72-121) - LS-C102578 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNX5 Antibody (aa400-412) - LS-C55503 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

SNX5 Antibody - NB100-1362 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

SNX5 Antibody - NBP1-58340 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Antibody - NBP2-38641 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Antibody - NBP2-20449 from Novus Biologicals Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Antibody - NBP2-20448 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody - bs-12248R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12248R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12248R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12248R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12248R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, Cy3 Conjugated - bs-12248R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, Cy5 Conjugated - bs-12248R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, Cy5.5 Conjugated - bs-12248R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, Cy7 Conjugated - bs-12248R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SNX5 Polyclonal Antibody, FITC Conjugated - bs-12248R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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