SNX5

Gene Symbol	SNX5
Entrez Gene	27131
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	sorting nexin 5
Other Description	sorting nexin-5
Swissprots	B7ZKN3 Q52LC4 D3DW26 Q7KZN0 Q9BWP0 Q9Y5X3
Accessions	EAX10263 EAX10264 EAX10265 EAX10266 EAX10267 EAX10268 Q9Y5X3 AF121855 AAD27828 AK001793 BAA91914 AK026227 AK054634 AK123903 BAG53980 AK129505 AK223308 BAD97028 AK296947 BAH12462 AK308017 AL832967 AW470866 BC000100 BC002724 BC062638 AAH62638 BC073171 BC093623 AAH93623 BC093980 AAH93980 BC143274 AAI43275 BT007191 AAP35855 DA567854 DB118420 NM_001282454 NP_001269383 NM_014426 NP_055241 NM_152227 NP_689413
Function	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved
Subcellular Location	Endosome {ECO:0000269|PubMed:11485546}. Early endosome {ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:24610942}. Early endosome membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:18854019}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. {ECO:0000269|PubMed:15561769, ECO:0000269|PubMed:16968745, ECO:0000269|PubMed:21048941}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SNX5 full length protein - ab202258 from Abcam Category Protein Source E. coli Species Human

Human SNX5 full length protein - ab40262 from Abcam Category Protein Source E. coli Species Human

Human SNX5 full length protein - ab182806 from Abcam Category Protein Source E. coli Species Human

SNX5 Antibody Blocking Peptide - LS-E25656 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNX5 Antibody Blocking Peptide - LS-E19869 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNX5 Antibody Blocking Peptide - LS-E19870 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNX5 Recombinant Protein - H00027131-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SNX5 Recombinant Protein - GTX48023-PRO from GeneTex Category Protein Prices $329.00 Sizes 50 μg Source E. coli Species Human

SNX5 blocking peptide - GTX25983-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Goat anti SNX5 antibody Immunizing peptide - orb17837 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

SNX5 Blocking Peptide - 33R-3126 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SNX5 protein - 80R-4203 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

SNX15 Peptide - AC21-0486-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Sorting nexin-5 (SNX5) (1-404, His-tag) - AR51885PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

Sorting nexin-5 (SNX5) (1-404, His-tag) - AR51885PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

Sorting nexin-5 (SNX5) - H00027131-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Sorting nexin-5 (SNX5) - H00027131-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SNX5 Peptide - 46-404P from ProSci Category Peptide Species Human

SNX5 Recombinant Protein - XW-RP3253 from ProSci Category Protein Prices $375.00 Sizes 50 µg Source E. coli Species Human

SNX5 fusion protein - Ag12330 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SNX5 fusion protein - Ag12993 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Sorting Nexin 5, T7-tagged - SNX5-1568H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human SNX5, GST-tagged - SNX5-2865H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human SNX5, His-tagged - SNX5-45H from Creative Biomart Category Protein Source E.coli Species Human

SNX5, 1-404aa, Human, His tag, E.coli - ATGP3065 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

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