NOTCH4

Gene Symbol	NOTCH4
Entrez Gene	4855
Alt Symbol	INT3
Species	Human
Gene Type	protein-coding
Description	notch 4
Other Description	Notch homolog 4|neurogenic locus notch homolog protein 4
Swissprots	Q9H3S8 B0V183 Q99458 Q5SSY7 B0V1X5 Q99466 Q9UIJ0 O00306 Q9UII9 Q99940
Accessions	AAC63097 BAA13116 BAA88951 BAA88952 BAB20317 Q99466 AK131314 AK290785 BAF83474 AK293692 BAG57129 AK294161 BAG57484 AL705928 BC033869 BC063815 AAH63815 BC140782 AAI40783 BC144540 BC144541 BQ023880 D63395 BAA09708 U95299 AAC32288 NM_004557 NP_004548
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
Top Pathways	Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NOTCH4 peptide - ab26877 from Abcam Category Peptide

NOTCH4 Antibody Blocking Peptide - LS-E27633 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOTCH4 Antibody Blocking Peptide - LS-E11505 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOTCH4 Antibody Blocking Peptide - LS-E13838 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOTCH4 Blocking Peptide - abx161184 from Abbexa Category Peptide Species Human, Mouse

NOTCH4 Peptide - AC21-2451-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NOTCH4 Peptide - 42-350P from ProSci Category Peptide

NOTCH4 fusion protein - ag18264 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NOTCH4 fusion protein - Ag18066 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human NOTCH4 - NOTCH4-309H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Notch Homolog 4 (NOTCH4) - RPL149Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Notch Homolog 4 (NOTCH4) - RPL149Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

NOTCH4 Blocking Peptide - CBP3683 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Human Neurogenic locus notch homolog protein 4(NOTCH4) ,partial - CSB-YP860341HU CSB-EP860341HU CSB-BP860341HU CSB-MP860341HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Notch Homolog 4 Protein (Recombinant) - abx166655 from Abbexa Category Protein Source Human Species Human

NOTCH4 Protein - abx163518 from Abbexa Category Protein Species Human, Mouse, Rat

NOTCH4, Peptide - MBS427720 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

NOTCH4 Blocking Peptide - abx061971 from Abbexa Category Peptide

NOTCH4-Antibody-C-term-Blocking-Peptide - BP6221a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NOTCH4-Blocking-Peptide-C-term - BP21426b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NOTCH4 Peptide, Human - M34GP10518H from Creative Peptides Category Peptide Source Synthetic. Species Human

NOTCH4 Blocking Peptide - CBP7361 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Monkey

NOTCH4 Immunizing peptide - orb66234 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg

Recombinant Notch Homolog 4 (NOTCH4) - RPU52352 from Biomatik Category Protein Prices $185.00, $378.00, $578.00, $688.80 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

NOTCH4 Recombinant Protein (OPCD05748) - OPCD05748 from Aviva Systems Biology Category Protein Source E.coli Species Human

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