NOTCH4

Gene Symbol NOTCH4
Entrez Gene 4855
Alt Symbol INT3
Species Human
Gene Type protein-coding
Description notch 4
Other Description Notch homolog 4|neurogenic locus notch homolog protein 4
Swissprots Q9H3S8 B0V183 Q99458 Q5SSY7 B0V1X5 Q99466 Q9UIJ0 O00306 Q9UII9 Q99940
Accessions AAC63097 BAA13116 BAA88951 BAA88952 BAB20317 Q99466 AK131314 AK290785 BAF83474 AK293692 BAG57129 AK294161 BAG57484 AL705928 BC033869 BC063815 AAH63815 BC140782 AAI40783 BC144540 BC144541 BQ023880 D63395 BAA09708 U95299 AAC32288 NM_004557 NP_004548
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
Top Pathways Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation

Notch 4 CRISPR/Cas9 KO Plasmid (h) - sc-400766 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 HDR Plasmid (h) - sc-400766-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 Double Nickase Plasmid (h) - sc-400766-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 Double Nickase Plasmid (h2) - sc-400766-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 CRISPR Activation Plasmid (h) - sc-400766-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 CRISPR Activation Plasmid (h2) - sc-400766-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 Lentiviral Activation Particles (h) - sc-400766-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 Lentiviral Activation Particles (h2) - sc-400766-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Notch 4 siRNA (h) - sc-40137 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Notch 4 shRNA Plasmid (h) - sc-40137-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Notch 4 shRNA (h) Lentiviral Particles - sc-40137-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Notch-4 RNAi - H00004855-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN15422 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15422 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04935 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04935

NOTCH4 siRNA (Human) - CRH3227 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NOTCH4(NM_004557.3) - SHR008706 from Creative biogene

Category siRNA
Species Reactivities Human

NOTCH4 shRNA Plasmid (Human) - CHH3227 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NOTCH4 miRNA 3'UTR clone - MiUTR1H-06856 from Creative biogene

Species Reactivities Human
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