Gene Symbol | HTR7 |
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Entrez Gene | 3363 |
Alt Symbol | 5-HT7 |
Species | Human |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
Other Description | 5-HT-7|5-HT-X|5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)|5-hydroxytryptamine receptor 7 |
Swissprots | Q5VX02 P78516 P34969 Q5VX01 P78372 B5BUP6 P78336 Q5VX03 |
Accessions | AAB48397 AAF07217 AAF07218 CAA66865 EAW50118 EAW50119 EAW50120 P34969 AB451482 BAG70296 AK292606 BAF85295 AY493988 AAR87480 BC047526 AAH47526 BG108256 L21195 AAC37538 U68487 AAB48393 U68488 AAB48394 NM_000872 NP_000863 NM_019859 NP_062873 NM_019860 NP_062874 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression. {ECO:0000269|PubMed:9084407}. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
SR-7 CRISPR/Cas9 KO Plasmid (h) - sc-404174 from Santa Cruz Biotechnology
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SR-7 HDR Plasmid (h) - sc-404174-HDR from Santa Cruz Biotechnology
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SR-7 Double Nickase Plasmid (h) - sc-404174-NIC from Santa Cruz Biotechnology
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SR-7 Double Nickase Plasmid (h2) - sc-404174-NIC-2 from Santa Cruz Biotechnology
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SR-7 CRISPR Activation Plasmid (h) - sc-404174-ACT from Santa Cruz Biotechnology
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SR-7 CRISPR Activation Plasmid (h2) - sc-404174-ACT-2 from Santa Cruz Biotechnology
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SR-7 Lentiviral Activation Particles (h) - sc-404174-LAC from Santa Cruz Biotechnology
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SR-7 Lentiviral Activation Particles (h2) - sc-404174-LAC-2 from Santa Cruz Biotechnology
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SR-7 siRNA (h) - sc-42246 from Santa Cruz Biotechnology
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SR-7 shRNA Plasmid (h) - sc-42246-SH from Santa Cruz Biotechnology
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SR-7 shRNA (h) Lentiviral Particles - sc-42246-V from Santa Cruz Biotechnology
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5-HT7 RNAi - H00003363-R04 from Novus Biologicals
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5-HT7 RNAi - H00003363-R05 from Novus Biologicals
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5-HT7 RNAi - H00003363-R06 from Novus Biologicals
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MISSION® esiRNA - EHU071661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10401 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10731 from Sigma-Aldrich
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HTR7 siRNA (Human) - CRH2293 from Cohesion Biosciences
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HTR7 - MBS8220047 from MyBioSource
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Human HTR7 siRNA - orb262795 from Biorbyt
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HTR7 shRNA Plasmid (Human) - CHH2293 from Cohesion Biosciences
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HTR7 miRNA 3'UTR clone - MiUTR3H-02092 from Creative biogene
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HTR7 miRNA 3'UTR clone - MiUTR3H-02093 from Creative biogene
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HTR7 miRNA 3'UTR clone - MiUTR3H-02094 from Creative biogene
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