| Gene Symbol |
NINL
|
| Entrez Gene |
22981
|
| Alt Symbol |
NLP, dJ691N24.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ninein-like
|
| Other Description |
ninein-like protein
|
| Swissprots |
Q9NQE3 Q5JYP0 A6NJN0 Q8NE38 B7Z1V8 Q9Y2I6 B3V9H6
|
| Accessions |
EAX10082 EAX10083 EAX10084 EAX10085 EAX10086 Q9Y2I6 AB023197 BAA76824 AI024623 AK021854 BAB13914 AK093569 AK293991 BAH11644 AK309298 BC036380 AAH36380 EU718622 ACE78295 XM_005260679 XP_005260736 XM_011529186 XP_011527488 XM_011529187 XP_011527489 XM_011529188 XP_011527490 XM_011529189 XP_011527491 XM_011529190 XP_011527492 XM_011529191 XP_011527493 XM_011529192 XP_011527494 XM_011529193 XP_011527495 XM_011529194 XP_011527496 XM_011529195 XP_011527497 XM_011529196 XP_011527498 XM_011529197 XP_011527499 XM_011529198 XP_011527500 NM_025176 NP_079452
|
| Function |
Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein- dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm.
|
| Tissue Specificity |
Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina. {ECO:0000269|PubMed:17403670, ECO:0000269|PubMed:18826961}.
|