NINL
| Gene Symbol | NINL |
|---|---|
| Entrez Gene | 22981 |
| Alt Symbol | NLP, dJ691N24.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ninein-like |
| Other Description | ninein-like protein |
| Swissprots | Q9NQE3 Q5JYP0 A6NJN0 Q8NE38 B7Z1V8 Q9Y2I6 B3V9H6 |
| Accessions | EAX10082 EAX10083 EAX10084 EAX10085 EAX10086 Q9Y2I6 AB023197 BAA76824 AI024623 AK021854 BAB13914 AK093569 AK293991 BAH11644 AK309298 BC036380 AAH36380 EU718622 ACE78295 XM_005260679 XP_005260736 XM_011529186 XP_011527488 XM_011529187 XP_011527489 XM_011529188 XP_011527490 XM_011529189 XP_011527491 XM_011529190 XP_011527492 XM_011529191 XP_011527493 XM_011529192 XP_011527494 XM_011529193 XP_011527495 XM_011529194 XP_011527496 XM_011529195 XP_011527497 XM_011529196 XP_011527498 XM_011529197 XP_011527499 XM_011529198 XP_011527500 NM_025176 NP_079452 |
| Function | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=In interphase cells, NINL is transported to the centrosomes by the dynein- dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm. |
| Tissue Specificity | Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina. {ECO:0000269|PubMed:17403670, ECO:0000269|PubMed:18826961}. |
NLP CRISPR/Cas9 KO Plasmid (h) - sc-406794 from Santa Cruz Biotechnology
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NLP HDR Plasmid (h) - sc-406794-HDR from Santa Cruz Biotechnology
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NLP Double Nickase Plasmid (h) - sc-406794-NIC from Santa Cruz Biotechnology
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NLP Double Nickase Plasmid (h2) - sc-406794-NIC-2 from Santa Cruz Biotechnology
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NLP CRISPR Activation Plasmid (h) - sc-406794-ACT from Santa Cruz Biotechnology
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NLP CRISPR Activation Plasmid (h2) - sc-406794-ACT-2 from Santa Cruz Biotechnology
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NLP Lentiviral Activation Particles (h) - sc-406794-LAC from Santa Cruz Biotechnology
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NLP Lentiviral Activation Particles (h2) - sc-406794-LAC-2 from Santa Cruz Biotechnology
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NLP siRNA (h) - sc-75931 from Santa Cruz Biotechnology
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NLP shRNA Plasmid (h) - sc-75931-SH from Santa Cruz Biotechnology
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NLP shRNA (h) Lentiviral Particles - sc-75931-V from Santa Cruz Biotechnology
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NINL RNAi - H00022981-R01 from Novus Biologicals
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MISSION® esiRNA - EHU096661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15298 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15298 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06345 from Sigma-Aldrich
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NINL siRNA (Human) - CRH7905 from Cohesion Biosciences
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NLP HDR Plasmid (h2) - sc-406794-HDR-2 from Santa Cruz Biotechnology
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NLP CRISPR/Cas9 KO Plasmid (h2) - sc-406794-KO-2 from Santa Cruz Biotechnology
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shRNA set against Human NINL (NM_025176.4) - SHH352444 from Creative biogene
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shRNA set against Human RP4-691N24.1(NM_025176.4) - SHR012784 from Creative biogene
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NINL shRNA Plasmid (Human) - CHH7905 from Cohesion Biosciences
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NINL miRNA 3'UTR clone - MiUTR1H-08951 from Creative biogene
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