VEGFA

Gene Symbol	VEGFA
Entrez Gene	7422
Alt Symbol	MVCD1, VEGF, VPF
Species	Human
Gene Type	protein-coding
Description	vascular endothelial growth factor A
Other Description	vascular permeability factor
Swissprots	O60720 H0Y414 Q9H1W9 Q9H1W8 Q6P0P5 Q96NW5 H0Y2S8 Q96L82 Q5UB46 P15692 B5BU86 H0Y462 O75875 H0Y8N2 Q16889 Q9UH58 H3BLW7 Q074Z4 Q96KJ0 Q9UL23 H0Y407
Accessions	AAA36804 AAD04918 AAL27630 CAH23417 CAI84576 CAJ32889 CAJ33665 CAL32723 CAL33850 CBH30534 CBH30539 EAX04227 EAX04228 EAX04229 EAX04230 EAX04231 EAX04232 EAX04233 EAX04234 EAX04235 P15692 AB021221 BAA78418 AB209485 BAD92722 AB451322 BAG70136 AB451451 BAG70265 AF022375 AAC63143 AF024710 AF062645 AAC16730 AF091352 AAD55345 AF214570 AAF19659 AF323587 AAQ14857 AF430806 AAL27435 AF486837 AAM03108 AJ010438 CAA09179 AK056914 AK125666 AY047581 AAK95847 AY263145 AAP86646 AY500353 AY766116 AAV34601 BC011177 AAH11177 BC019867 BC058855 BC065522 AAH65522 BC172307 AAI72307 BF700556 BM661679 BQ880667 BU153227 BX442364 CN256173 CX756573 DA237741 DQ229900 ABB58912 EU832814 ACE87825 GQ129408 ACT64542 HY066915 M27281 AAA36807 M32977 AAA35789 S85192 AAC63102 X62568 CAA44447 NM_001025366 NP_001020537 NM_001025367 NP_001020538 NM_001025368 NP_001020539 NM_001025369 NP_001020540 NM_001025370 NP_001020541 NM_001033756 NP_001028928 NM_001171622 NP_001165093 NM_001171623 NP_001165094 NM_001171624 NP_001165095 NM_001171625 NP_001165096 NM_001171626 NP_001165097 NM_001171627 NP_001165098 NM_001171628 NP_001165099 NM_001171629 NP_001165100 NM_001171630 NP_001165101 NM_001204384 NP_001191313 NM_001204385 NP_001191314 NM_001287044 NP_001273973 NM_003376 NP_003367
Function	Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. {ECO:0000269|PubMed:11427521, ECO:0000269|PubMed:16489009}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11563986, ECO:0000269|PubMed:11731620, ECO:0000269|PubMed:15896327}. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
Tissue Specificity	Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269|PubMed:22009797}.
Top Pathways	Proteoglycans in cancer, MicroRNAs in cancer, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human VEGF 121B full length protein - ab88348 from Abcam Category Protein Prices $341.00 Sizes 5 µg Source HEK 293 cells Species Human

Active human VEGF 121B full length protein - ab61872 from Abcam Category Protein Prices $200.00 Sizes 10 µg Source E. coli Species Human

Active human VEGF 121B full length protein - ab86935 from Abcam Category Protein Prices $309.00, $1,279.00 Sizes 50 µg, 500 µg Source E. coli Species Human

Active human VEGF 165A full length protein - ab179624 from Abcam Category Protein Prices $291.00 Sizes 10 µg Source E. coli Species Human

Active human VEGF 165A full length protein - ab180026 from Abcam Category Protein Prices $895.00 Sizes 100 µg Source E. coli Species Human

Active human VEGF 165A full length protein - ab83572 from Abcam Category Protein Prices $340.00 Sizes 5 µg Source HEK 293 cells Species Human

Active human VEGF 165A full length protein - ab192110 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active human VEGF 165A protein fragment - ab168684 from Abcam Category Protein Prices $394.00 Sizes 25 µg Source HEK 293 cells Species Human

Active human VEGF 165A protein fragment - ab61861 from Abcam Category Protein Prices $200.00 Sizes 10 µg Source E. coli Species Human

Active human VEGF 165A protein fragment - ab56620 from Abcam Category Protein Prices $315.00 Sizes 20 µg Source E. coli Species Human

Active human VEGF full length protein - ab9571 from Abcam Category Protein Prices $110.00, $257.00 Sizes 2 µg, 10 µg Source E. coli Species Human

Active human VEGF full length protein - ab53824 from Abcam Category Protein Prices $196.00 Sizes 5 µg Source E. coli Species Human

Active human VEGF full length protein - ab181896 from Abcam Category Protein Prices $1,529.00 Sizes 100 µg Source E. coli Species Human

Active human VEGF full length protein - ab187239 from Abcam Category Protein Prices $291.00 Sizes 10 µg Source E. coli Species Human

Active human VEGF protein fragment - ab73277 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source CHO Species Human

Active human VEGF189 full length protein - ab106307 from Abcam Category Protein Prices $315.00 Sizes 5 µg Source E. coli Species Human

Active human VEGFA full length protein - ab155740 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source HEK 293 cells Species Human

Active human VEGFA protein fragment - ab155722 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source HEK 293 cells Species Human

Active mouse VEGF 165A full length protein - ab62134 from Abcam Category Protein Prices $200.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse VEGF 165A full length protein - ab200239 from Abcam Category Protein Prices $101.00 Sizes 2 µg Source E. coli Species Mouse

Active mouse VEGF protein fragment - ab191623 from Abcam Category Protein Prices $371.00 Sizes 10 µg Source HEK 293 cells Species Mouse

Active mouse VEGF protein fragment - ab73279 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source Insect cells Species Mouse

Active mouse VEGFA full length protein - ab185265 from Abcam Category Protein Prices $529.00 Sizes 10 µg Source HEK 293 cells Species Mouse

Active mouse VEGFA full length protein - ab200260 from Abcam Category Protein Prices $101.00 Sizes 2 µg Source E. coli Species Mouse

Active mouse VEGFA full length protein - ab191787 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Mouse

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