VEGFA

Gene Symbol VEGFA
Entrez Gene 7422
Alt Symbol MVCD1, VEGF, VPF
Species Human
Gene Type protein-coding
Description vascular endothelial growth factor A
Other Description vascular permeability factor
Swissprots O60720 H0Y414 Q9H1W9 Q9H1W8 Q6P0P5 Q96NW5 H0Y2S8 Q96L82 Q5UB46 P15692 B5BU86 H0Y462 O75875 H0Y8N2 Q16889 Q9UH58 H3BLW7 Q074Z4 Q96KJ0 Q9UL23 H0Y407
Accessions AAA36804 AAD04918 AAL27630 CAH23417 CAI84576 CAJ32889 CAJ33665 CAL32723 CAL33850 CBH30534 CBH30539 EAX04227 EAX04228 EAX04229 EAX04230 EAX04231 EAX04232 EAX04233 EAX04234 EAX04235 P15692 AB021221 BAA78418 AB209485 BAD92722 AB451322 BAG70136 AB451451 BAG70265 AF022375 AAC63143 AF024710 AF062645 AAC16730 AF091352 AAD55345 AF214570 AAF19659 AF323587 AAQ14857 AF430806 AAL27435 AF486837 AAM03108 AJ010438 CAA09179 AK056914 AK125666 AY047581 AAK95847 AY263145 AAP86646 AY500353 AY766116 AAV34601 BC011177 AAH11177 BC019867 BC058855 BC065522 AAH65522 BC172307 AAI72307 BF700556 BM661679 BQ880667 BU153227 BX442364 CN256173 CX756573 DA237741 DQ229900 ABB58912 EU832814 ACE87825 GQ129408 ACT64542 HY066915 M27281 AAA36807 M32977 AAA35789 S85192 AAC63102 X62568 CAA44447 NM_001025366 NP_001020537 NM_001025367 NP_001020538 NM_001025368 NP_001020539 NM_001025369 NP_001020540 NM_001025370 NP_001020541 NM_001033756 NP_001028928 NM_001171622 NP_001165093 NM_001171623 NP_001165094 NM_001171624 NP_001165095 NM_001171625 NP_001165096 NM_001171626 NP_001165097 NM_001171627 NP_001165098 NM_001171628 NP_001165099 NM_001171629 NP_001165100 NM_001171630 NP_001165101 NM_001204384 NP_001191313 NM_001204385 NP_001191314 NM_001287044 NP_001273973 NM_003376 NP_003367
Function Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. {ECO:0000269|PubMed:11427521, ECO:0000269|PubMed:16489009}.
Subcellular Location Secreted {ECO:0000269|PubMed:11563986, ECO:0000269|PubMed:11731620, ECO:0000269|PubMed:15896327}. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
Tissue Specificity Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269|PubMed:22009797}.
Top Pathways Proteoglycans in cancer, MicroRNAs in cancer, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway

VEGF (147) - sc-507 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of human recombinant VEGF. Antibodies tested include VEGF (147): sc-507 (A) and VEGF (A-20): sc-152 (B).

VEGF (F-5) - sc-365578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VEGF (F-5): sc-365578. Western blot analysis of human recombinant VEGF fusion protein.

VEGF (C-1) - sc-7269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VEGF (C-1): sc-7269. Western blot analysis of human recombinant VEGF.

VEGF (A-20) - sc-152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VEGF (A-20): sc-152. Western blot analysis of reduced (A) and unreduced (B) purified VEGF protein (20 ng).

VEGF (VG-1) - sc-53462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VEGF (VG-1): sc-53462. Western blot analysis of biologically active human recombinant VEGF (A) and mouse recombinant VEGF (B).

VEGF (VG76e) - sc-53463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VEGF (VG76e): sc-53463. Western blot analysis of purified human VEGF.

VEGF (SPM225) - sc-65617 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

VEGF (JH121) - sc-57496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
VEGF (JH121): sc-57496. Western blot analysis of VEGF expression in non-transfected: sc-117752 (A) and human VEGF transfected: sc-117031 (B) 293T whole cell lysates.

Anti-VEGF 164 antibody - ab53465 from Abcam

Prices $450.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-VEGF 164 antibody (ab53465) at 1/500 dilution + Thymus (Human) Tissue Lysate - adult normal tissue (ab30146) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-VEGF 165A antibody - ab106580 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-VEGF 165A antibody (ab106580) at 1/1000 dilution + Recombinant Human VEGF 165ASecondaryPeroxidase conjugated anti-Rabbit IgG at 1/40000 dilution

Anti-VEGF 165A antibody - ab150766 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-VEGF 165A antibody (ab150766) at 1/1000 dilution + recombinant Human VEGF 165A protein

Anti-VEGF 165A antibody [6B7] - ab69479 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6B7
Anti-VEGF 165A antibody [6B7] (ab69479) + VEGF at 0.1 µg

Anti-VEGF 165B antibody - ab90719 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-VEGF 165B antibody (ab90719) at 1 µg/ml + VEGF 165B Recombinant Protein at 0.1 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-VEGF antibody - ab46154 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VEGF antibody (ab46154) at 1 µgLane 1 : MEF whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : MCF7 whole cell lysateLane 4 : NIH 3T3 whole cell lysateLane 5 : RCC4 whole cell lysateLane 6 : PC12 whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-mouse IgG (IRDye 800) at 1/10000 dilutionPerformed under reducing conditions.

Anti-VEGF antibody - ab39250 from Abcam

Prices $385.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab39250 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab39250, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-VEGF antibody - ab17696 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-VEGF antibody [11B5] - ab38909 from Abcam

Prices $376.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 11B5

Anti-VEGF antibody [5C3.F8] - ab3109 from Abcam

Prices $390.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 5C3.F8
ab3109 staining VEGF in mouse islet grafts by Immunohistochemistry (FFPE-sections).

Anti-VEGF antibody [5C3.F8] - ab81881 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C3.F8

Anti-VEGF antibody [6D3] - ab36424 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6D3

Anti-VEGF antibody (Biotin) - ab83132 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Detected human VEGF in a sandwich ELISA within the range 16-1000 pg/ml - 0.5 µg/ml of capture antibody (ab9570) - 0.25 µg/ml of detection antibody (ab83132)

Anti-VEGF antibody (Biotin) - ab17710 from Abcam

Host Goat
Clonality Polyclonal

Anti-VEGF antibody [EP1176Y] - ab52917 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1176Y
ab52917 staining VEGF in Mouse kidney tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde, permeabilized with 0.3% Triton X-100 and blocked with 5% serum for 45 minutes at 25°C. Samples were incubated with primary antibody (1/400 in 4% BSA + 5% serum in PBST) for 14 hours at 4°C. An Alexa Fluor® 546-conjugated Donkey anti-rabbit IgG polyclonal (1/300) was used as the secondary antibody.See Abreview

Anti-VEGF antibody (HRP) - ab106041 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VEGF antibody [JH121] - ab28775 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JH121
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