| Gene Symbol |
RHPN2
|
| Entrez Gene |
85415
|
| Alt Symbol |
P76RBE, RHOBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
rhophilin, Rho GTPase binding protein 2
|
| Other Description |
76 kDa RhoB effector protein|GTP-Rho-binding protein 2|rhophilin 2|rhophilin-2|rhophilin-like Rho-GTPase binding protein
|
| Swissprots |
Q8N9D6 Q8NE33 Q8N3T7 Q96RU1 B3KUY8 Q8IUC4 B4DUS7 B2RCG8
|
| Accessions |
Q8IUC4 AF268032 AAK58588 AF423421 AAQ04062 AJ347750 CAC87939 AK026894 AK095001 BAC04471 AK098246 BAG53600 AK126506 BAG54339 AK300775 BAG62439 AK315105 BAG37565 AL831950 CAD38597 BC036447 AAH36447 DC348657 DQ892111 ABM83037 DQ895305 ABM86231 NM_033103 NP_149094
|
| Function |
Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:12473120}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver. {ECO:0000269|PubMed:12221077, ECO:0000269|PubMed:12473120}.
|