Gene Symbol | RHPN2 |
---|---|
Entrez Gene | 85415 |
Alt Symbol | P76RBE, RHOBP |
Species | Human |
Gene Type | protein-coding |
Description | rhophilin, Rho GTPase binding protein 2 |
Other Description | 76 kDa RhoB effector protein|GTP-Rho-binding protein 2|rhophilin 2|rhophilin-2|rhophilin-like Rho-GTPase binding protein |
Swissprots | Q8N9D6 Q8NE33 Q8N3T7 Q96RU1 B3KUY8 Q8IUC4 B4DUS7 B2RCG8 |
Accessions | Q8IUC4 AF268032 AAK58588 AF423421 AAQ04062 AJ347750 CAC87939 AK026894 AK095001 BAC04471 AK098246 BAG53600 AK126506 BAG54339 AK300775 BAG62439 AK315105 BAG37565 AL831950 CAD38597 BC036447 AAH36447 DC348657 DQ892111 ABM83037 DQ895305 ABM86231 NM_033103 NP_149094 |
Function | Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000269|PubMed:12473120}. |
Tissue Specificity | Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver. {ECO:0000269|PubMed:12221077, ECO:0000269|PubMed:12473120}. |
Rhophilin-2 CRISPR/Cas9 KO Plasmid (h) - sc-413777 from Santa Cruz Biotechnology
|
||||||||
Rhophilin-2 HDR Plasmid (h) - sc-413777-HDR from Santa Cruz Biotechnology
|
||||||||
Rhophilin-2 Double Nickase Plasmid (h) - sc-413777-NIC from Santa Cruz Biotechnology
|
||||||||
Rhophilin-2 Double Nickase Plasmid (h2) - sc-413777-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Rhophilin-2 CRISPR Activation Plasmid (h) - sc-413777-ACT from Santa Cruz Biotechnology
|
||||||||
Rhophilin-2 CRISPR Activation Plasmid (h2) - sc-413777-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Rhophilin-2 Lentiviral Activation Particles (h) - sc-413777-LAC from Santa Cruz Biotechnology
|
||||||||
Rhophilin-2 Lentiviral Activation Particles (h2) - sc-413777-LAC-2 from Santa Cruz Biotechnology
|
||||||||
rhophilin-2 siRNA (h) - sc-62938 from Santa Cruz Biotechnology
|
||||||||
rhophilin-2 shRNA Plasmid (h) - sc-62938-SH from Santa Cruz Biotechnology
|
||||||||
rhophilin-2 shRNA (h) Lentiviral Particles - sc-62938-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU105401 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN18269 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18269 from Sigma-Aldrich
|
||||||||
RHPN2 siRNA (Human) - CRJ3803 from Cohesion Biosciences
|
||||||||
RHPN2 - MBS8209197 from MyBioSource
|
||||||||
shRNA set against Human RHPN2 (NM_033103.4) - SHH395624 from Creative biogene
|
||||||||
Human RHPN2 siRNA - orb274304 from Biorbyt
|
||||||||
RHPN2 shRNA Plasmid (Human) - CHJ3803 from Cohesion Biosciences
|
||||||||
RHPN2 miRNA 3'UTR clone - MiUTR3H-15893 from Creative biogene
|