Gene Symbol | ASH2L |
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Entrez Gene | 9070 |
Alt Symbol | ASH2, ASH2L1, ASH2L2, Bre2 |
Species | Human |
Gene Type | protein-coding |
Description | ash2 (absent, small, or homeotic)-like (Drosophila) |
Other Description | ASH2-like protein|set1/Ash2 histone methyltransferase complex subunit ASH2 |
Swissprots | Q96B62 O60659 D3DSW9 A8K7C3 Q9UBL3 O60660 |
Accessions | BAA74520 EAW63336 EAW63337 EAW63338 EAW63339 EAW63340 Q9UBL3 AB020982 BAA35127 AF056717 AAC13563 AF056718 AAC13564 AK291750 BAF84439 AK291938 BAF84627 AK293699 BAG57134 AK298483 BAG60693 AK311336 AW962440 BC015936 AAH15936 CA417078 DA156139 DC326351 DC353644 DC396707 XM_005273682 XP_005273739 XM_005273683 XP_005273740 XM_006716412 XP_006716475 XM_006716413 XP_006716476 NM_001105214 NP_001098684 NM_001261832 NP_001248761 NM_001282272 NP_001269201 NM_004674 NP_004665 |
Function | Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19556245}. |
Subcellular Location | Nucleus {ECO:0000305|PubMed:17355966}. |
Tissue Specificity | Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. {ECO:0000269|PubMed:10393421}. |
Human ASH2L full length protein - ab135008 from Abcam
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Human ASH2L protein fragment - ab176944 from Abcam
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ASH2L / ASH2 Antibody Blocking Peptide - LS-E12107 from LifeSpan Bioscience
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ASH2L / ASH2 Antibody Blocking Peptide - LS-E12106 from LifeSpan Bioscience
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ASH2L / ASH2 Antibody Blocking Peptide - LS-E25184 from LifeSpan Bioscience
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ASH2L / ASH2 Antibody Blocking Peptide - LS-E21275 from LifeSpan Bioscience
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ASH2L Recombinant Protein - H00009070-P01 from Novus Biologicals
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Recombinant Human ASH2L Protein - H00009070-Q01 from Novus Biologicals
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Human ASH2L protein - orb244978 from Biorbyt
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ASH2L / ASH2L1 - H00009070-P01 from Acris Antibodies
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ASH2L / ASH2L1 - H00009070-P01-10 from Acris Antibodies
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ASH2L / ASH2L1 - H00009070-Q01-10 from Acris Antibodies
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ASH2L / ASH2L1 - H00009070-Q01-25 from Acris Antibodies
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ASH2L fusion protein - ag3008 from Proteintech Group
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Ash2L, Human Recombinant Protein - GWB-PS464B from Genway Biotech
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Recombinant Human ASH2L, GST-tagged - ASH2L-9933H from Creative Biomart
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Recombinant Human Set1/Ash2 histone methyltransferase complex subunit ASH2(ASH2L) - CSB-YP883363HU CSB-BP883363HU CSB-MP883363HU from Cusabio
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Recombinant human Set1/Ash2 histone methyltransferase complex subunit ASH2 - CSB-EP883363HU from Cusabio
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Ash2L (96-628 aa), Human recombinant - 7664-25 from Biovision
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ASH2L / ASH2L1 (transcript variant 1) - TP315552 from Acris Antibodies
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Ash2L, Recombinant Protein - MBS844242 from MyBioSource
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ASH2L Recombinant Protein Antigen - NBP1-88858PEP from Novus Biologicals
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ASH2L-Antibody-Center-Blocking-Peptide - BP9648c from Abgent, a WuXi AppTec company
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ASH2L-Blocking-Peptide-Center - BP20971a from Abgent, a WuXi AppTec company
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ASH2L-Blocking-Peptide-Center - BP20970a from Abgent, a WuXi AppTec company
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