Gene Symbol | ASH2L |
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Entrez Gene | 9070 |
Alt Symbol | ASH2, ASH2L1, ASH2L2, Bre2 |
Species | Human |
Gene Type | protein-coding |
Description | ash2 (absent, small, or homeotic)-like (Drosophila) |
Other Description | ASH2-like protein|set1/Ash2 histone methyltransferase complex subunit ASH2 |
Swissprots | Q96B62 O60659 D3DSW9 A8K7C3 Q9UBL3 O60660 |
Accessions | BAA74520 EAW63336 EAW63337 EAW63338 EAW63339 EAW63340 Q9UBL3 AB020982 BAA35127 AF056717 AAC13563 AF056718 AAC13564 AK291750 BAF84439 AK291938 BAF84627 AK293699 BAG57134 AK298483 BAG60693 AK311336 AW962440 BC015936 AAH15936 CA417078 DA156139 DC326351 DC353644 DC396707 XM_005273682 XP_005273739 XM_005273683 XP_005273740 XM_006716412 XP_006716475 XM_006716413 XP_006716476 NM_001105214 NP_001098684 NM_001261832 NP_001248761 NM_001282272 NP_001269201 NM_004674 NP_004665 |
Function | Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19556245}. |
Subcellular Location | Nucleus {ECO:0000305|PubMed:17355966}. |
Tissue Specificity | Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. {ECO:0000269|PubMed:10393421}. |
ASH2L CRISPR/Cas9 KO Plasmid (h) - sc-403172 from Santa Cruz Biotechnology
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ASH2L HDR Plasmid (h) - sc-403172-HDR from Santa Cruz Biotechnology
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ASH2 Double Nickase Plasmid (h) - sc-403172-NIC from Santa Cruz Biotechnology
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ASH2L Double Nickase Plasmid (h2) - sc-403172-NIC-2 from Santa Cruz Biotechnology
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ASH2 CRISPR Activation Plasmid (h) - sc-403172-ACT from Santa Cruz Biotechnology
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ASH2L CRISPR Activation Plasmid (h2) - sc-403172-ACT-2 from Santa Cruz Biotechnology
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ASH2 Lentiviral Activation Particles (h) - sc-403172-LAC from Santa Cruz Biotechnology
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ASH2L Lentiviral Activation Particles (h2) - sc-403172-LAC-2 from Santa Cruz Biotechnology
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ASH2L siRNA (h) - sc-43556 from Santa Cruz Biotechnology
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ASH2L shRNA Plasmid (h) - sc-43556-SH from Santa Cruz Biotechnology
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ASH2L shRNA (h) Lentiviral Particles - sc-43556-V from Santa Cruz Biotechnology
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ASH2L RNAi - H00009070-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN3597 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3597 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04322 from Sigma-Aldrich
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ASH2L siRNA (Human) - CRH5987 from Cohesion Biosciences
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ASH2L - MBS8207196 from MyBioSource
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shRNA set against Human ASH2L (NM_004674.4) - SHH241490 from Creative biogene
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Human ASH2L siRNA - orb266489 from Biorbyt
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ASH2L shRNA Plasmid (Human) - CHH5987 from Cohesion Biosciences
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ASH2L miRNA 3'UTR clone - MiUTR3H-07085 from Creative biogene
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ASH2L miRNA 3'UTR clone - MiUTR3H-07086 from Creative biogene
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