| Gene Symbol |
SEH1L
|
| Entrez Gene |
81929
|
| Alt Symbol |
SEC13L, SEH1A, SEH1B, Seh1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SEH1-like (S. cerevisiae)
|
| Other Description |
nucleoporin SEH1|nup107-160 subcomplex subunit SEH1|sec13 like protein|sec13-like protein
|
| Swissprots |
Q96MH3 A8K5B1 Q9C069 Q8NFU6 Q96EE3
|
| Accessions |
EAX01530 EAX01531 Q96EE3 AF136976 AAG49437 AF255625 AAM21169 AF431970 AAM44214 AF514996 AAM76707 AK056940 BAB71317 AK226075 AK291226 BAF83915 AK314403 BC012430 AAH12430 BX538037 CB990796 HQ447878 ADQ32362 XM_005258152 XP_005258209 XM_011525742 XP_011524044 XM_011525743 XP_011524045 XM_011525744 XP_011524046 XM_011525745 XP_011524047 XM_011525746 XP_011524048 XR_935069 NM_001013437 NP_001013455 NM_031216 NP_112493
|
| Function |
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900, ECO:0000269|PubMed:23723238}.
|
| Subcellular Location |
Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
|
| Top Pathways |
RNA transport
|