SETD2

Gene Symbol SETD2
Entrez Gene 29072
Alt Symbol HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, SET2, p231HBP
Species Human
Gene Type protein-coding
Description SET domain containing 2
Other Description histone-lysine N-methyltransferase SETD2|huntingtin interacting protein 1|huntingtin yeast partner B|huntingtin-interacting protein B|lysine N-methyltransferase 3A
Swissprots Q8TCN0 Q6ZS25 O75405 Q9C0D1 Q8N3R0 Q9BYW2 Q5QGN2 Q6ZN53 O75397 Q9H696 Q9NZW9 Q6IN64 Q17RW8 Q5BKS9 Q69YI5
Accessions EAW64805 EAW64806 EAW64807 EAW64808 EAW64809 EAW64810 EAW64811 Q9BYW2 AB051519 BAB21823 AF049103 AAC26194 AF049610 AAC26846 AF161554 AAF29041 AI671342 AJ238403 CAC28349 AK026125 BAB15367 AK026837 AK091413 AK095494 AK127782 BAC87131 AK128096 AK131371 BAD18522 AL049470 AL713692 CAD28492 AL831959 CAD38601 AL833394 CAH10589 AY576987 AAT77612 AY576988 AAT77613 BC072440 AAH72440 BC090954 AAH90954 BC117162 AAI17163 BC117164 AAI17165 BF437034 BX649110 DA800082 XM_011533631 XP_011531933 XM_011533632 XP_011531934 XM_011533633 XP_011531935 XM_011533634 XP_011531936 XR_940418 XR_940419 XR_940420 NM_014159 NP_054878 NM_012271
Function Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing i
Subcellular Location Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:11461154}.
Top Pathways Lysine degradation

Hif1 alpha+ GLUT Hypoxia Human In Cell ELISA Kit (IR) - ab125298 from Abcam

Category ELISA Kit
Prices $438.00
Sizes 1 x 96 tests
Sample experiment using ab125298 on HeLa cells treated with a titration of DFO. HeLa cells were seeded to an amine coated 96-well microplate and the following day treated with a titration of DFO. After 24h of DFO exposure, the cells were fixed and stained as described in the protocol and the normalized data is presented here +/- SD (as described in the protocol and data analysis sections). HIF1 alpha results show DFO concentrations >10µM induce HIF1A protein levels in a dose dependent manner.

SET domain containing 2, ELISA Kit - MBS9337367 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml
Range 0.625ng/ml-20ng/ml

SET domain containing 2, setd2, ELISA Kit - MBS9305592 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human HIF-1 ELISA Kit - E019194 from Biobool

Category ELISA Kit

Human SETD2 ELISA Kit - E034993 from Biobool

Category ELISA Kit

anti-KMT3A / SETD2 antibody - ARG54749 from Arigo Biolaboratories

Category ELISA Kit

anti-KMT3A / SETD2 antibody - ARG64368 from Arigo Biolaboratories

Category ELISA Kit

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9373713 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9377213 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9380506 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9372532 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9378949 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9373795 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9381871 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9377242 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9374486 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9376377 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9372160 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9373154 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9379968 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9370278 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9376764 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9378264 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9371616 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone-Lysine N-Methyltransferase SETD2 (SETD2), ELISA Kit - MBS9380392 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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