SETD2

Gene Symbol SETD2
Entrez Gene 29072
Alt Symbol HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, SET2, p231HBP
Species Human
Gene Type protein-coding
Description SET domain containing 2
Other Description histone-lysine N-methyltransferase SETD2|huntingtin interacting protein 1|huntingtin yeast partner B|huntingtin-interacting protein B|lysine N-methyltransferase 3A
Swissprots Q8TCN0 Q6ZS25 O75405 Q9C0D1 Q8N3R0 Q9BYW2 Q5QGN2 Q6ZN53 O75397 Q9H696 Q9NZW9 Q6IN64 Q17RW8 Q5BKS9 Q69YI5
Accessions EAW64805 EAW64806 EAW64807 EAW64808 EAW64809 EAW64810 EAW64811 Q9BYW2 AB051519 BAB21823 AF049103 AAC26194 AF049610 AAC26846 AF161554 AAF29041 AI671342 AJ238403 CAC28349 AK026125 BAB15367 AK026837 AK091413 AK095494 AK127782 BAC87131 AK128096 AK131371 BAD18522 AL049470 AL713692 CAD28492 AL831959 CAD38601 AL833394 CAH10589 AY576987 AAT77612 AY576988 AAT77613 BC072440 AAH72440 BC090954 AAH90954 BC117162 AAI17163 BC117164 AAI17165 BF437034 BX649110 DA800082 XM_011533631 XP_011531933 XM_011533632 XP_011531934 XM_011533633 XP_011531935 XM_011533634 XP_011531936 XR_940418 XR_940419 XR_940420 NM_014159 NP_054878 NM_012271
Function Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing i
Subcellular Location Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:11461154}.
Top Pathways Lysine degradation

HYPB (D-19) - sc-99451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HYPB (D-19): sc-99451. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

HYPB (S-12) - sc-99452 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HYPB (S-12): sc-99452. Western blot analysis of HYPB expression in Jurkat nuclear extract.

HYPB (T-18) - sc-99453 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-KMT3A / HYPB / HIF-1 antibody - ab31358 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KMT3A / HYPB / HIF-1 antibody (ab31358) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lane 3 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell Lysate Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) (ab65484) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KMT3A / HYPB / HIF-1 antibody - ab69836 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KMT3A / HYPB / HIF-1 antibody (ab69836) at 1.25 µg/mlLane 1 : HepG2 cell lysateLane 2 : HepG2 cell lysateLane 3 : HepG2 cell lysateLane 4 : Molecular weight markerSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KMT3A / HYPB / HIF-1 antibody - ab184190 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KMT3A / HYPB / HIF-1 antibody (ab184190) at 1/1000 dilutionLane 1 : Raji whole cell lysateLane 2 : K562 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-KMT3A / HYPB / HIF-1 antibody - C-terminal - ab197840 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling KMT3A / HYPB / HIF-1 with ab197840 at 1/40.

Anti-SETD2 Antibody (C-Terminus, FITC) - LS-C244717 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (C-Terminus, APC) - LS-C244713 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (C-Terminus, Biotin) - LS-C244715 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (C-Terminus, PE) - LS-C244718 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (aa21-50, Azide-free, HRP) - LS-C248126 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (aa21-50) - LS-C325026 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (C-Terminus, Azide-free, HRP) - LS-C247639 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (C-Terminus) - LS-C327592 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody - LS-C341561 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (aa1787-2144, clone 1B4) - LS-C339024 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SETD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SETD2.

Anti-SETD2 Antibody (aa323-372) - LS-C81092 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SETD2 antibody LS-C81092 was used in IHC to stain formalin-fixed, paraffin-embedded human placenta.

Anti-SETD2 Antibody (aa1787-2144, clone 3G8) - LS-C339110 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SETD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SETD2.

Anti-SETD2 Antibody (aa1787-2144, clone 1C4) - LS-C339001 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C4
Human recombinant protein fragment corresponding to amino acids 1787-2144 of human SETD2 (NP_054878) produced in E.coli.

Anti-SETD2 Antibody (aa1787-2144, clone 1E1) - LS-C339155 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E1
IHC of paraffin-embedded Human embryonic liver tissue using anti-SETD2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-SETD2 Antibody - LS-C332416 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using SETD2 antibody.

Anti-SETD2 Antibody (aa2062-2073) - LS-C54991 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SETD2 Antibody (aa21-50, AP) - LS-C240615 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SETD2 Antibody (aa21-50, APC) - LS-C240616 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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