SETD2

Gene Symbol	SETD2
Entrez Gene	29072
Alt Symbol	HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, SET2, p231HBP
Species	Human
Gene Type	protein-coding
Description	SET domain containing 2
Other Description	histone-lysine N-methyltransferase SETD2|huntingtin interacting protein 1|huntingtin yeast partner B|huntingtin-interacting protein B|lysine N-methyltransferase 3A
Swissprots	Q8TCN0 Q6ZS25 O75405 Q9C0D1 Q8N3R0 Q9BYW2 Q5QGN2 Q6ZN53 O75397 Q9H696 Q9NZW9 Q6IN64 Q17RW8 Q5BKS9 Q69YI5
Accessions	EAW64805 EAW64806 EAW64807 EAW64808 EAW64809 EAW64810 EAW64811 Q9BYW2 AB051519 BAB21823 AF049103 AAC26194 AF049610 AAC26846 AF161554 AAF29041 AI671342 AJ238403 CAC28349 AK026125 BAB15367 AK026837 AK091413 AK095494 AK127782 BAC87131 AK128096 AK131371 BAD18522 AL049470 AL713692 CAD28492 AL831959 CAD38601 AL833394 CAH10589 AY576987 AAT77612 AY576988 AAT77613 BC072440 AAH72440 BC090954 AAH90954 BC117162 AAI17163 BC117164 AAI17165 BF437034 BX649110 DA800082 XM_011533631 XP_011531933 XM_011533632 XP_011531934 XM_011533633 XP_011531935 XM_011533634 XP_011531936 XR_940418 XR_940419 XR_940420 NM_014159 NP_054878 NM_012271
Function	Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing i
Subcellular Location	Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11461154}.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KMT3A / HYPB / HIF-1 peptide - ab32693 from Abcam Category Peptide

SETD2 Antibody Blocking Peptide - LS-E26502 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HYPB/SETD2 (C Terminus) blocking peptide - GTX89236-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

HYPB/SETD2 (internal region) blocking peptide - GTX88922-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

SETD2 Blocking Peptide - 33R-8347 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KMT3A / HYPB / HIF-1 Peptide - AC21-1338-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HYPB Peptide - 45-757P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Mouse

Recombinant SET2 protein - 31358 from ActiveMotif Category Protein Prices $395.00 Sizes 50 µg Source E. coli Species Human

Recombinant SETD2 (1392-2564) protein - 31399 from ActiveMotif Category Protein Prices $425.00 Sizes 20 µg Source Baculovirus Species Human

Recombinant Human SET Domain Containing 2, GST-tagged - SETD2-460H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human SETD2 - SETD2-27850TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SETD2, GST-tagged - SETD2-461H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human SETD2, FLAG-tagged - SETD2-69H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human Histone-lysine N-methyltransferase SETD2(SETD2) ,partial - CSB-YP871619HU CSB-EP871619HU CSB-BP871619HU CSB-MP871619HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Chlamydophila caviae 60 kDa chaperonin 1(groL1) ,partial - CSB-YP321379DSL CSB-EP321379DSL CSB-BP321379DSL CSB-MP321379DSL from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

Recombinant Chlamydia trachomatis 60 kDa chaperonin(groL) ,partial - CSB-YP314770DSB CSB-EP314770DSB CSB-BP314770DSB CSB-MP314770DSB from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Chlamydia

HYPB/SETD2, Peptide - MBS426506 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Pig

Recombinant Human SETD2 Protein, GST-tagged - SETD2-188H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human SETD2 Protein, His-tagged - SETD2-189H from Creative Biomart Category Protein Source E.coli Species Human

HYPB Recombinant Protein Antigen - NBP1-89843PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SET2-Antibody-C-term-Blocking-Peptide - BP1196b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SET2-Antibody-N-term-Blocking-Peptide - BP1196a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SETD2 Peptide, Human - M34GP14079H from Creative Peptides Category Peptide Source Synthetic. Species Human

Histone-lysine N-methyltransferase SETD2 (SETD2), partial, Recombinant Protein - MBS1475711 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SETD2, Recombinant Protein - MBS515669 from MyBioSource Category Protein Prices $325.00, $500.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

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