SLC29A4

Gene Symbol	SLC29A4
Entrez Gene	222962
Alt Symbol	ENT4, PMAT
Species	Human
Gene Type	protein-coding
Description	solute carrier family 29 (equilibrative nucleoside transporter), member 4
Other Description	equilibrative nucleoside transporter 4|plasma membrane monoamine transporter|solute carrier family 29 (nucleoside transporters), member 4|solute carrier family 29 member 4
Swissprots	Q8NBM2 Q6PJ08 Q7RTT9 Q86WY8 Q8NAR3
Accessions	DAA00308 EAW87329 EAW87330 Q7RTT9 AK075422 BAC11612 AK092242 BAC03836 AK296278 BAG58987 AL515106 AY485959 AAS65965 BC025325 AAH25325 BC047592 AAH47592 BM069878 BU740709 H07897 XM_005249658 XP_005249715 XM_006715667 XP_006715730 XM_006715668 XP_006715731 XM_011515200 XP_011513502 XM_011515201 XP_011513503 NM_001040661 NP_001035751 NM_001300847 NP_001287776 NM_153247 NP_694979
Function	Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to chang
Subcellular Location	Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718}.
Tissue Specificity	Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes putamen and in the spinal cord. Lower expression in liver, pancreas, and liver. Expressed in endometrial tissue, exclusively in the stroma. Expression is high in the proliferative phase, decreases during the secretory phase, and is no longer detectable in the menstrual phase. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17393420}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ENT4 (V-12) - sc-164272 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ENT4 (SA-18) - sc-101295 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-SLC29A4 antibody - ab56554 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SLC29A4 antibody - Carboxyterminal end - ab71382 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

SLC29A4 Antibody (6B6) - H00222962-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6B6

SLC29A4 Antibody - H00222962-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

SLC29A4 Antibody - NBP2-41314 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody - bs-4176R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4-Antibody-monoclonal-M03 - AT3918a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6B6

SLC29A4(Tyr198) Polyclonal Antibody - bs-5637R from Bioss Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-4176R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-4176R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-4176R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-4176R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, Cy3 Conjugated - bs-4176R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, Cy5 Conjugated - bs-4176R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, Cy5.5 Conjugated - bs-4176R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, Cy7 Conjugated - bs-4176R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, FITC Conjugated - bs-4176R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, Biotin Conjugated - bs-4176R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC29A4 Polyclonal Antibody, HRP Conjugated - bs-4176R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PMAT Antibody - abx025965 from Abbexa Host Rabbit Clonality Polyclonal

PMAT Antibody - abx025966 from Abbexa Host Rabbit Clonality Polyclonal

SLC29A4 / ENT4 antibody - H00222962-A01 from Acris Antibodies Prices $300.00 Sizes 50 µl Host Mouse Clonality Polyclonal

SLC29A4 / ENT4 antibody - H00222962-M03 from Acris Antibodies Prices $360.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 6B6

Search more