SLC29A4

Gene Symbol	SLC29A4
Entrez Gene	222962
Alt Symbol	ENT4, PMAT
Species	Human
Gene Type	protein-coding
Description	solute carrier family 29 (equilibrative nucleoside transporter), member 4
Other Description	equilibrative nucleoside transporter 4|plasma membrane monoamine transporter|solute carrier family 29 (nucleoside transporters), member 4|solute carrier family 29 member 4
Swissprots	Q8NBM2 Q6PJ08 Q7RTT9 Q86WY8 Q8NAR3
Accessions	DAA00308 EAW87329 EAW87330 Q7RTT9 AK075422 BAC11612 AK092242 BAC03836 AK296278 BAG58987 AL515106 AY485959 AAS65965 BC025325 AAH25325 BC047592 AAH47592 BM069878 BU740709 H07897 XM_005249658 XP_005249715 XM_006715667 XP_006715730 XM_006715668 XP_006715731 XM_011515200 XP_011513502 XM_011515201 XP_011513503 NM_001040661 NP_001035751 NM_001300847 NP_001287776 NM_153247 NP_694979
Function	Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to chang
Subcellular Location	Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718}.
Tissue Specificity	Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes putamen and in the spinal cord. Lower expression in liver, pancreas, and liver. Expressed in endometrial tissue, exclusively in the stroma. Expression is high in the proliferative phase, decreases during the secretory phase, and is no longer detectable in the menstrual phase. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17393420}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ENT4 CRISPR/Cas9 KO Plasmid (h) - sc-405115 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 HDR Plasmid (h) - sc-405115-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 Double Nickase Plasmid (h) - sc-405115-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 Double Nickase Plasmid (h2) - sc-405115-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 CRISPR Activation Plasmid (h) - sc-405115-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 CRISPR Activation Plasmid (h2) - sc-405115-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 Lentiviral Activation Particles (h) - sc-405115-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 Lentiviral Activation Particles (h2) - sc-405115-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ENT4 siRNA (h) - sc-89525 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ENT4 shRNA Plasmid (h) - sc-89525-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ENT4 shRNA (h) Lentiviral Particles - sc-89525-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU150531 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19543 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19543 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07995 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07995

SLC29A4 siRNA (Human) - CRJ6585 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SLC29A4 RNAi - H00222962-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

SLC29A4 - MBS8200701 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SLC29A4(NM_001040661.1) - SHL005372 from Creative biogene Category siRNA Species Reactivities Human

Human SLC29A4 siRNA - orb277086 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SLC29A4 shRNA Plasmid (Human) - CHJ6585 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SLC29A4 miRNA 3'UTR clone - MiUTR1H-09511 from Creative biogene Species Reactivities Human

SLC29A4 miRNA 3'UTR clone - MiUTR3H-10437 from Creative biogene Species Reactivities Human

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